Which shock drug is safest? large ICU trial aims to find out

NCT ID NCT02118467

Recruiting now Disease control Sponsor: University of Chicago Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests four different drugs (norepinephrine, epinephrine, phenylephrine, and vasopressin) in ICU patients with shock that doesn't improve with fluids. The goal is to see which drug causes fewer dangerous heart rhythm problems and improves survival. About 836 adults will take part, and the drugs are given through a central line.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: norepinephrine, epinephrine, phenylephrine, vasopressin
What this could lead to: If successful, this could identify which vasoactive drug is safest for ICU shock patients, potentially reducing dangerous heart rhythm issues and improving survival.
What could go wrong: This is a single-center trial, so results may not apply everywhere. The drugs are already in use, so no major breakthrough is expected—just better guidance for doctors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atrial fibrillation diabetes insipidus Shock Tachycardia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SHOCK

Contacts and locations

Locations

University of Chicago Medical Center
RECRUITING

Chicago, Illinois, 60637, United States

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