One-Size-Fits-All sepsis care challenged: new study tests tailored fluids

NCT ID NCT07009665

Recruiting now Disease control Sponsor: University Medical Center Groningen Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether giving fluids and blood pressure medicines based on each patient's heart response can improve sepsis care. 188 adults with sepsis in the emergency department will be randomly assigned to either personalized treatment or standard care. The goal is to see if the personalized approach uses less fluid, starts medicines earlier, and leads to safer recovery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: IV fluids and vasopressors
What this could lead to: If successful, this could lead to safer, more effective sepsis treatment by tailoring fluids to each patient's heart response, reducing complications like fluid overload.
What could go wrong: This is a small, early-phase study (188 participants) at one hospital. The personalized approach may not improve outcomes or could be harder to implement in busy ERs.

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Conditions

The condition(s) this trial relates to.

infectious disease with sepsis Sepsis Shock

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CRITICAL CARE, FLUID RESUSCITATION EMERGENCY MEDICINE FLUID RESPONSIVENESS PERSONALIZED MEDICINE SEPSIS SHOCK

Contacts and locations

Locations

University Medical Centre Groningen
RECRUITING

Groningen, Provincie Groningen, 9713GZ, Netherlands

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