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The hidden breath: how a mismatch between patient and machine may shape ARDS recovery

NCT ID NCT06148467

Knowledge-focused Sponsor: Hospital Civil de Guadalajara Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 16, 2026 · Last updated Sep 17, 2026 · Updated 1 time

Summary

Researchers at Hospital Civil de Guadalajara are observing mechanically ventilated patients with acute respiratory distress syndrome (ARDS) to measure how often a breathing mismatch called reverse trigger occurs. They monitor patients continuously with esophageal manometry from the time sedation or muscle relaxants stop, or when spontaneous breathing begins, until patients switch to a spontaneous breathing mode, need deep sedation again, or die. The study also tracks how patients respond when doctors adjust the ventilator. The goal is to understand the real frequency of reverse trigger and whether ventilator tweaks change it.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If researchers map how reverse trigger behaves, ventilator settings could be tuned to reduce this breathing mismatch and possibly shorten time on a machine.
What could go wrong
This is an observational study, so it cannot prove that adjusting the ventilator improves outcomes. Findings from 130 patients in one hospital may not apply everywhere.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 130 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2023

Expected to finish

Feb 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Mechanically ventilated patients with acute respiratory distress syndrome.

Ages

18 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of ARDS according to the Berlin criteria and added New Global Definition 2023 * Mechanical ventilation Exclusion Criteria: * \<18 years * Tracheostomy status * Pneumothorax * Tube thoracostomy with air leaks

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Conditions

The condition(s) this trial relates to.

acute respiratory distress syndrome adult acute respiratory distress syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute respiratory distress syndrome Mechanical ventilation Reverse trigger

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hospital Civil Fray Antonio Alcalde

    RECRUITING

    Guadalajara, 44280, Mexico

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