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Breathing machine settings put to the test in severe lung injury

NCT ID NCT04221737

Disease control Sponsor: Hospital Civil de Guadalajara Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 17, 2026 · Last updated Sep 18, 2026 · Updated 1 time

Summary

Acute respiratory distress syndrome (ARDS) is a life-threatening lung injury that often requires a breathing machine. This trial compares two ways of using that machine: airway pressure release ventilation (APRV), which holds the lungs open longer with brief releases, and conventional mechanical ventilation. Researchers are enrolling about 150 adults with ARDS to see which approach helps patients breathe without the machine for more days.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Airway pressure release ventilation (APRV), a breathing machine mode that holds the lungs open longer and releases briefly
What this could lead to
If APRV works better than standard ventilation, it could give intensive care teams a way to help ARDS patients spend fewer days on a breathing machine.
What could go wrong
ARDS is a severe, fast-moving lung injury, and this trial compares two existing breathing strategies rather than testing a new drug. Results may not show a clear winner, and the findings may not apply to all hospital settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2017

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Acute respiratory distress syndrome, according to the Berlin definition of ARDS, with adjusted pO2/FiO2 for altitude \<300, and less than 48 h of endotracheal mechanical ventilation Exclusion Criteria: * Pregnancy * Less than 18 years-old * Expected duration of mechanical ventilation less than 48 h * Preexisting conditions with an expected 3-month mortality exceeding 50% * Concurrent chemotherapy * Confirmed intracranial hypertension * Catastrophic cranial trauma or neuromuscular disorders that are known to prolong mechanical ventilation * Pneumothorax at enrollment (resolved or not) * Do-not-resuscitate order

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Conditions

The condition(s) this trial relates to.

acute lung injury acute respiratory distress syndrome adult acute respiratory distress syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute respiratory distress syndrome

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hospital Civil Fray Antonio Alcalde

    RECRUITING

    Guadalajara, Jalisco, 44280, Mexico

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