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Scientists hunt for hidden subgroups in sudden respiratory failure

NCT ID NCT05150483

Knowledge-focused Sponsor: Evangelismos Hospital Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
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Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
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Status unknown
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First seen Sep 15, 2026 · Last updated Sep 16, 2026 · Updated 1 time

Summary

Researchers at Evangelismos Hospital are studying adults who arrive in the emergency department with sudden acute hypoxemic respiratory failure, a condition where the blood oxygen drops dangerously low. The team collects clinical, imaging, physiological, and biological data early in the illness, including protein biomarkers. They aim to identify distinct biological subgroups, called endotypes, that may share a similar risk of death or lasting severe hypoxemia. The study plans to enroll 350 participants and follows them to see which early variables relate to outcomes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If researchers can group patients by their biology, doctors may one day match treatments to the right subgroup and improve survival.
What could go wrong
This is an observational study, so it cannot prove that any subgroup or biomarker causes outcomes. The clusters may not hold up in other hospitals or patient groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 350 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2021

Expected to finish

Jul 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients presenting in the emergency department with de novo acute hypoxemic respiratory failure

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients (aged \>18 years) presenting in the emergency department * De novo acute hypoxemic respiratory failure (requiring oxygen flow rate of 5 liters per minute or more to maintain SpO2 of 90% or more) Exclusion Criteria: * Age \<18 years * Not admitted to the hospital * Postoperative acute respiratory failure (within one week from surgery) * Chronic hypoxemic respiratory failure (requiring long term oxygen therapy at home) * Hypercapnic respiratory failure * Transferred from another hospital or facility * Pregnant women * Admitted to the hospital purely to facilitate comfort care * Lack of informed consent

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Conditions

The condition(s) this trial relates to.

acute respiratory distress syndrome acute respiratory failure adult acute respiratory distress syndrome Critical Illness Emergencies respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute hypoxemic respiratory failure Acute respiratory distress syndrome

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Evangelismos Hospital

    RECRUITING

    Athens, Attica, 10676, Greece

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