Cancer-Killing virus shows promise in early trial for advanced tumors

NCT ID NCT05076760

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase trial is testing a new treatment called MEM-288, a virus designed to infect and kill cancer cells while also boosting the immune system. The study involves 40 adults with advanced solid tumors, including lung, skin, and breast cancers, who have not responded to standard treatments. MEM-288 is injected directly into accessible tumors, either alone or combined with standard therapies like nivolumab or docetaxel. The main goals are to find the safest dose and check for any early signs of tumor shrinkage.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
MEM-288 oncolytic virus (a modified virus that targets and kills cancer cells)
What this could lead to
If successful, this could point toward a new treatment option for advanced solid tumors that have not responded to other therapies.
What could go wrong
This is a very early Phase 1 trial with only 40 participants, so safety and effectiveness are not yet proven. The virus is injected directly into tumors, which may not be possible for all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Duke Cancer Institute

    COMPLETED

    Durham, North Carolina, 27710, United States

  • Moffitt Cancer Center

    RECRUITING

    Tampa, Florida, 33612, United States

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