Could a shorter antibiotic course be just as good for leg infections?
NCT ID NCT05584007
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial compares a 5-day course of the antibiotic flucloxacillin to the standard 7-day course for adults with leg cellulitis. About 334 participants will receive either 5 days of active drug plus 2 days of placebo, or 7 days of active drug. The goal is to see if the shorter course is non-inferior in controlling pain and preventing recurrence, which could lead to less antibiotic use and fewer side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- flucloxacillin
- What this could lead to
- If successful, this could show that a shorter course of antibiotics is just as effective, reducing side effects and antibiotic resistance.
- What could go wrong
- This is a non-inferiority trial, so it may find that 5 days is slightly less effective. Results may not apply to severe cases or people with allergies.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Royal South Hants Hospital
RECRUITINGSouthampton, United Kingdom
More trials for these conditions
Other studies related to the condition(s) this trial covers.