University Of Southampton

This phase 3 trial compares a 5-day course of the antibiotic flucloxacillin to the standard 7-day course for adults with leg cellulitis. About 334 participants will receive either 5 days of active drug plus 2 days of placebo, or 7 days of active drug. The goal is to see if the sh…

This study tests whether a lower dose of heated chemotherapy given during surgery works as well as a higher dose for people with pseudomyxoma peritonei, a rare cancer that spreads in the abdomen. About 176 participants will be randomly assigned to receive either the lower dose ov…

This study tests a new type of ureteric stent designed to cause fewer blockages, infections, and less pain than standard stents. About 50 adults who have had stents before for kidney stones or cancer will try the new stent. The goal is to see if it reduces complications and the n…

This study will intentionally expose 72 healthy adults to the bacteria that cause whooping cough to see how the body fights it off without immediate antibiotics. Participants will be monitored closely for up to 6 weeks before receiving antibiotics to clear the infection. The goal…

This study looks at whether trained volunteers can help older adults (65+) in the hospital stay active and avoid losing strength and mobility. About 180 participants will either get twice-daily volunteer-led walks or bedside exercises, or usual care. Researchers will interview pa…