Lower dose of heated chemo may be just as effective for rare abdominal cancer

NCT ID NCT06513065

Recruiting now Disease control Sponsor: University of Southampton Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a lower dose of heated chemotherapy given during surgery works as well as a higher dose for people with pseudomyxoma peritonei, a rare cancer that spreads in the abdomen. About 176 participants will be randomly assigned to receive either the lower dose over 60 minutes or the higher dose over 90 minutes. The goal is to see if the lower dose can control the cancer just as well while causing fewer side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Mitomycin C (heated chemotherapy given during surgery)
What this could lead to: If the lower dose works as well, it could mean fewer complications for patients while still controlling the cancer effectively.
What could go wrong: This is a single study with 176 participants, so results may not apply to everyone. The lower dose might be less effective at preventing cancer return.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

pseudomyxoma peritonei

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PSEUDOMYXOMA PERITONEI

Contacts and locations

Locations

Peritoneal Malignancy Institute Basingstoke - Hampshire Hospitals NHS Foundation Trust
RECRUITING

Basingstoke, Hampshire, United Kingdom

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