New drug EVOLVE104 takes on tough cancers in early human trial
NCT ID NCT07217171
First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 5 times
Summary
This early-stage trial is testing an experimental drug called EVOLVE104 in people with advanced bladder cancer or several types of squamous cell carcinoma (lung, esophagus, skin, and others). The study aims to find a safe dose and see if the drug can shrink tumors. It is for patients who have already tried standard treatments or cannot take them. About 160 participants will receive the drug by IV infusion.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- EVOLVE104 (an experimental drug given by IV infusion)
- What this could lead to
- If it works, this could point toward a new treatment option for advanced bladder and squamous cell cancers that have not responded to standard therapies.
- What could go wrong
- This is a very early Phase 1 trial with only 160 participants, so the drug may not prove effective or safe enough for wider use. Side effects are unknown and could be serious.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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City of Hope
RECRUITINGDuarte, California, 91010, United States
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Columbia University Irving Medical Center
RECRUITINGNew York, New York, 10032, United States
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Icahn School of Medicine at Mount Sinai
RECRUITINGNew York, New York, 10029, United States
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MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
Contact Email: •••••@•••••
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
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SCRI
RECRUITINGNashville, Tennessee, 37203, United States
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START Midwest
RECRUITINGGrand Rapids, Michigan, 49546, United States
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The Winship Cancer Institute Emory University
RECRUITINGAtlanta, Georgia, 30322, United States
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Thomas Jefferson University, Sidney Kimmel Cancer Center
RECRUITINGPhiladelphia, Pennsylvania, 19107, United States
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USC/Norris Comprehensive Cancer Center
RECRUITINGLos Angeles, California, 90033, United States
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University Hospitals Cleveland Medical Center
RECRUITINGCleveland, Ohio, 44106, United States
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Virginia Cancer Specialists
RECRUITINGFairfax, Virginia, 22031, United States
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Yale University Cancer Center
RECRUITINGNew Haven, Connecticut, 06511, United States
More trials for these conditions
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- Can Pre-Surgery chemotherapy outsmart aggressive bladder cancer?
- Can adding radiation boost the power of immunotherapy in advanced cervical cancer?
- Can a new drug combo shrink Hard-to-Treat tumors?