New oral drug shows promise for rare sun allergy conditions

NCT ID NCT05005975

Recruiting now Disease control Sponsor: Tanabe Pharma America, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 12, 2026 · Updated 2 times

Summary

This study is for people with erythropoietic protoporphyria (EPP) or X-linked protoporphyria (XLP), rare conditions that cause severe pain and skin reactions to sunlight. The purpose is to check the long-term safety of an oral medication called dersimelagon. About 301 participants who completed a previous dersimelagon study will take the drug and be monitored for side effects over an extended period.

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Conditions

The condition(s) this trial relates to.

erythropoietic protoporphyria protoporphyria, erythropoietic, 1 X-linked erythropoietic protoporphyria X-linked lymphoproliferative disease due to SH2D1A deficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EPP XLP

Contacts and locations

Locations

Assistance Publique-Hopitaux de Paris (AP-HP) - Hopital Louis-Mourier
ACTIVE_NOT_RECRUITING

Colombes, 92700, France
Azienda Ospedaliera Spedali Civili di Brescia-Universita degli Studi Di Brescia
ACTIVE_NOT_RECRUITING

Brescia BS, 25123, Italy
Azienda Sanitaria Ospedaliera Santa Croce E Carle - Cuneo
ACTIVE_NOT_RECRUITING

Cuneo CN, 12100, Italy
CHU Nantes
ACTIVE_NOT_RECRUITING

Nantes, 44000, France
Centre Hospitalier Universitaire de Bordeaux - Hopital Saint - Andre
ACTIVE_NOT_RECRUITING

Bordeaux, 33000, France
Charite - Universitaetsmedizin Berlin
ACTIVE_NOT_RECRUITING

Berlin, 10117, Germany
Erasmus MC, Universitair Medisch Centrum Rotterdam
ACTIVE_NOT_RECRUITING

Rotterdam, 3015 GD, Netherlands
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico di Milano
ACTIVE_NOT_RECRUITING

Milan, 20122, Italy
Hamamatsu University Hospital
ACTIVE_NOT_RECRUITING

Shizuoka, 431-3125, Japan
Haukeland University Hospital
ACTIVE_NOT_RECRUITING

Bergen, N5021, Norway
Henry Ford Health System
ACTIVE_NOT_RECRUITING

Detroit, Michigan, 48202, United States
Hospital Bichat-Hopitaux Universitaires Paris Nord Val de Seine
ACTIVE_NOT_RECRUITING

Paris, 75018, France
Hospital Clínic de Barcelona
ACTIVE_NOT_RECRUITING

Barcelona, 8036, Spain
Hospital General Universitario De Valencia
ACTIVE_NOT_RECRUITING

Valencia, 46014, Spain
Hospital Universitario
ACTIVE_NOT_RECRUITING

Madrid, 28041, Spain
I.F.O. Hospital, Centro Porfirie e Malattie Rare
ACTIVE_NOT_RECRUITING

Roma, Rome, 128, Italy
Icahn School of Medicine at Mount Sinai (ISSMS)-The Mount Sinai Hospital (MSH)
ACTIVE_NOT_RECRUITING

New York, New York, 10029, United States
Institute for Clinical and Experimental Medicine - IKEM
ACTIVE_NOT_RECRUITING

Prague, 140 21, Czechia
Instytut hematologii i Transfuzjologii
ACTIVE_NOT_RECRUITING

Warsaw, 02-776, Poland
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Materno-Infantile - Burlo Garofolo - Clinica Pediatrica
ACTIVE_NOT_RECRUITING

Trieste TS, 34137, Italy
Kansas City Research Institute
ACTIVE_NOT_RECRUITING

Kansas City, Missouri, 64131, United States
Karolinska University Hospital
ACTIVE_NOT_RECRUITING

Stockholm, 14186, Sweden
Kobe University Hospital
ACTIVE_NOT_RECRUITING

Kobe, Hyōgo, 650-0017, Japan
Marvel Clinical Research, LLC
ACTIVE_NOT_RECRUITING

Huntington Beach, California, 92647, United States
Massachusetts General Hospital
ACTIVE_NOT_RECRUITING

Boston, Massachusetts, 02114, United States
MetroBoston Clinical Partners, LLC
ACTIVE_NOT_RECRUITING

Brighton, Massachusetts, 02135-3211, United States
Osaka Medical College Hospital
ACTIVE_NOT_RECRUITING

Takatsuki, Osaka, 569-8686, Japan
Ospedalle Galliera
ACTIVE_NOT_RECRUITING

Genova GE, 16128, Italy
Remington-Davis Clinical Research
ACTIVE_NOT_RECRUITING

Columbus, Ohio, 43215, United States
Royal Melbourne Hospital (RMH)
ACTIVE_NOT_RECRUITING

Parkville, Victoria, 3050, Australia
Salford Royal NHS Foundation Trust
ACTIVE_NOT_RECRUITING

Manchester, MN, M6 8HD, United Kingdom
Sophia Dermatology Clinic
ACTIVE_NOT_RECRUITING

Kanazawa, Ishikawa-ken, 921-8035, Japan
St. John's Institute of Dermatology-Guy's & St Thomas' NHS Foundation Trust
ACTIVE_NOT_RECRUITING

London, SE1 7EH, United Kingdom
The University of Texas Medical Branch (UTMB)
ACTIVE_NOT_RECRUITING

Galveston, Texas, 77555, United States
Thomas Jefferson University
ACTIVE_NOT_RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Tokyo Saiseikai Central Hospital
ACTIVE_NOT_RECRUITING

Minato-ku, Tokyo, 108-0073, Japan
Toyama University Hospital
ACTIVE_NOT_RECRUITING

Sugitani, Toyama, 930-0194, Japan
U.O.C. Medicina Interna Azienda ospedaliero Universitaria Policlinico di Modena
ACTIVE_NOT_RECRUITING

Modena, 41125, Italy
University Multi-Profile Hospital for Active Treatment (UMHAT) St. Ivan Rilski
ACTIVE_NOT_RECRUITING

Sofia, 1000, Bulgaria
University Of Miami School Of Medicine, Center For Liver Diseases
ACTIVE_NOT_RECRUITING

Miami, Florida, 33136, United States
University of Alberta Hospital
ACTIVE_NOT_RECRUITING

Edmonton, Alberta, Edmonton AB T6G 2G3, Canada
University of California at San Francisco - CSF Porphyria Center
ACTIVE_NOT_RECRUITING

San Francisco, California, 94143, United States
University of Washington-Seattle Cancer Care Alliance
RECRUITING

Seattle, Washington, 98109, United States
Wake Forest University Baptist Health
ACTIVE_NOT_RECRUITING

Winston-Salem, North Carolina, 27157, United States
Wesley Medical Research
ACTIVE_NOT_RECRUITING

Brisbane, Queensland, 4066, Australia

More trials for these conditions

Other studies related to the condition(s) this trial covers.

New drug may let people with rare sun allergy enjoy the outdoors longer