New combo therapy aims to tame returning head and neck cancer

NCT ID NCT07156227

First seen Nov 01, 2025 · Last updated May 10, 2026 · Updated 32 times

Summary

This early-stage trial tests a drug called camonsertib combined with precise, high-dose radiation for people whose head and neck cancer has come back or cannot be removed by surgery. The study will include about 39 adults and aims to find the safest dose and see if the combination can control the disease. The drug works by blocking a protein that cancer cells need to grow, while the radiation targets tumors directly.

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Conditions

Explore the condition pages connected to this study.

CLINICAL STAGE III HPV-MEDIATED (P16-POSITIVE) OROPHARYNGEAL CARCINOMA AJCC V8 RECURRENT HEAD AND NECK SQUAMOUS CELL CARCINOMA RECURRENT HYPOPHARYNGEAL SQUAMOUS CELL CARCINOMA RECURRENT LARYNGEAL SQUAMOUS CELL CARCINOMA RECURRENT ORAL CAVITY SQUAMOUS CELL CARCINOMA RECURRENT ORAL CAVITY SQUAMOUS CELL CARCINOMA RECURRENT OROPHARYNGEAL SQUAMOUS CELL CARCINOMA RECURRENT OROPHARYNGEAL SQUAMOUS CELL CARCINOMA RECURRENT PARANASAL SINUS SQUAMOUS CELL CARCINOMA STAGE III HEAD AND NECK CUTANEOUS SQUAMOUS CELL CARCINOMA AJCC V8 STAGE III HEAD AND NECK CUTANEOUS SQUAMOUS CELL CARCINOMA AJCC V8 STAGE III HYPOPHARYNGEAL CARCINOMA AJCC V8 STAGE III HYPOPHARYNGEAL CARCINOMA AJCC V8 STAGE III LARYNGEAL CANCER AJCC V8 STAGE III LARYNGEAL CANCER AJCC V8 STAGE III LIP AND ORAL CAVITY CANCER AJCC V8 STAGE III LIP AND ORAL CAVITY CANCER AJCC V8 STAGE III OROPHARYNGEAL (P16-NEGATIVE) CARCINOMA AJCC V8 STAGE III OROPHARYNGEAL (P16-NEGATIVE) CARCINOMA AJCC V8 STAGE III SINONASAL CANCER AJCC V8 STAGE III SINONASAL CANCER AJCC V8 STAGE IV HEAD AND NECK CUTANEOUS SQUAMOUS CELL CARCINOMA AJCC V8 STAGE IV HEAD AND NECK CUTANEOUS SQUAMOUS CELL CARCINOMA AJCC V8 STAGE IVA HYPOPHARYNGEAL CARCINOMA AJCC V8 STAGE IVA HYPOPHARYNGEAL CARCINOMA AJCC V8 STAGE IVA LARYNGEAL CANCER AJCC V8 STAGE IVA LARYNGEAL CANCER AJCC V8 STAGE IVA LIP AND ORAL CAVITY CANCER AJCC V8 STAGE IVA LIP AND ORAL CAVITY CANCER AJCC V8 STAGE IVA OROPHARYNGEAL (P16-NEGATIVE) CARCINOMA AJCC V8 STAGE IVA OROPHARYNGEAL (P16-NEGATIVE) CARCINOMA AJCC V8 STAGE IVA SINONASAL CANCER AJCC V8 STAGE IVA SINONASAL CANCER AJCC V8 STAGE IVB HYPOPHARYNGEAL CARCINOMA AJCC V8 STAGE IVB HYPOPHARYNGEAL CARCINOMA AJCC V8 STAGE IVB LARYNGEAL CANCER AJCC V8 STAGE IVB LARYNGEAL CANCER AJCC V8 STAGE IVB LIP AND ORAL CAVITY CANCER AJCC V8 STAGE IVB LIP AND ORAL CAVITY CANCER AJCC V8 STAGE IVB OROPHARYNGEAL (P16-NEGATIVE) CARCINOMA AJCC V8 STAGE IVB OROPHARYNGEAL (P16-NEGATIVE) CARCINOMA AJCC V8 STAGE IVB SINONASAL CANCER AJCC V8 STAGE IVB SINONASAL CANCER AJCC V8 UNRESECTABLE HEAD AND NECK SQUAMOUS CELL CARCINOMA UNRESECTABLE HYPOPHARYNGEAL SQUAMOUS CELL CARCINOMA UNRESECTABLE LARYNGEAL SQUAMOUS CELL CARCINOMA UNRESECTABLE ORAL CAVITY SQUAMOUS CELL CARCINOMA UNRESECTABLE ORAL CAVITY SQUAMOUS CELL CARCINOMA UNRESECTABLE OROPHARYNGEAL SQUAMOUS CELL CARCINOMA UNRESECTABLE PARANASAL SINUS SQUAMOUS CELL CARCINOMA