Could a shorter antibiotic course for lyme disease be just as effective?
NCT ID NCT03337932
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This trial is testing whether a 7-day course of doxycycline works as well as the standard 14-day course for people with multiple erythema migrans, a sign of early Lyme disease. About 200 participants will be randomly assigned to one of the two treatment durations. Researchers will track symptoms and any new Lyme-related problems for up to a year to see if the shorter treatment is enough.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- doxycycline
- What this could lead to
- If successful, this could show that a 7-day course of doxycycline is just as effective as the standard 14-day course for treating multiple erythema migrans, potentially reducing antibiotic use and side effects.
- What could go wrong
- This is a relatively small trial (200 participants) and results may not apply to all Lyme disease cases. The study is still recruiting, so findings are preliminary and could show no significant difference between the two treatment durations.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University Medical center Ljubljana
RECRUITINGLjubljana, Slovenia