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Massive T-Cell lymphoma database aims to unlock new insights

NCT ID NCT05978141

Knowledge-focused Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is creating a large database of information and tissue samples from 1,000 people with T-cell lymphoma. Researchers will use this data to learn more about the disease and how to improve patient outcomes. Participants provide medical information and optional blood and nail samples.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this database could help researchers discover better ways to diagnose and treat T-cell lymphoma in the future.
What could go wrong
This is an observational registry, not a treatment trial. It will not directly benefit participants and may not lead to immediate breakthroughs.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 1,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2023

Expected to finish

Jul 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants at Memorial Sloan Kettering Cancer Center (MSKCC) will be recruited through the Lymphoma service in the Department of Medicine and the Department of Pediatrics. Participants will be recruited at the participating centers.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Written informed consent * Adequate fresh or archival tumor biopsy or intent to obtain fresh tumor biopsy. * Pathologically-confirmed mature T- or natural killer (NK)-cell lymphoma meeting one of the following diagnostic criterion (based on WHO classification and NCCN guidelines): * T-cell prolymphocytic leukemia * T-cell large granular lymphocytic leukemia * Chronic lymphoproliferative disorder of NK cells * Aggressive NK-cell leukemia * Systemic Epstein-Barr virus (EBV)-positive T-cell lymphoma of childhood * Chronic active EBV infection of T- and NK-cell type, systemic form * Hydroa vacciniforme-like lymphoproliferative disorder * Adult T-cell leukemia/lymphoma * Extranodal NK/T-cell lymphoma, nasal type * Enteropathy-associated T-cell lymphoma * Monomorphic epitheliotropic intestinal T-cell lymphoma * Intestinal T-cell lymphoma, not otherwise specified (NOS) * Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract * Hepatosplenic T-cell lymphoma * Subcutaneous panniculitis-like T-cell lymphoma * Mycosis fungoides (limited to those with ≥ stage IB disease and those receiving active therapy) * Sézary syndrome * Primary cutaneous anaplastic large cell lymphoma (receiving systemic therapy) * Primary cutaneous Gamma-Delta T-cell lymphoma * Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma * Primary cutaneous acral CD8+ T-cell lymphoma (receiving systemic therapy) * Peripheral T-cell lymphoma, not otherwise specified * Angioimmunoblastic T-cell lymphoma * Follicular T-cell lymphoma * Nodal peripheral T-cell lymphoma with TFH phenotype * Anaplastic large cell lymphoma, ALK-positive * Anaplastic large cell lymphoma, ALK-negative * Breast-implant associated anaplastic large cell lymphoma. * NOTE: Patients with diagnoses of mycosis fungoides, primary cutaneous anaplastic large cell lymphoma, and/or primary cutaneous acral CD8+ T-cell lymphoma must be receiving systemic therapy. Exclusion Criteria: * Patients with of mycosis fungoides, primary cutaneous anaplastic large cell lymphoma, and/or primary cutaneous acral CD8+ T-cell lymphoma not receiving systemic therapy. * Inability to collect prospective data, measure response, or perform adequate follow-up assessments in the clinical judgment of the treating physician. NOTE: Repository participation does not exclude participation in clinical trials, nor does existing clinical trial participation exclude enrollment in the study herein outlined.

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Conditions

The condition(s) this trial relates to.

adult T-cell leukemia/lymphoma aggressive NK-cell leukemia ALK-negative anaplastic large cell lymphoma ALK-positive anaplastic large cell lymphoma anaplastic large cell lymphoma angioimmunoblastic T-cell lymphoma breast implant-associated anaplastic large cell lymphoma chronic lymphoproliferative disorder of NK-cells enteropathy-associated T-cell lymphoma extranodal nasal NK/T cell lymphoma hepatosplenic T-cell lymphoma hydroa vacciniforme-like lymphoma Leukemia, Large Granular Lymphocytic Lymphoma, Extranodal NK-T-Cell monomorphic epitheliotropic intestinal T-cell lymphoma mycosis fungoides peripheral T-cell lymphoma, not otherwise specified Precursor T-Cell Lymphoblastic Leukemia-Lymphoma primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma primary cutaneous anaplastic large cell lymphoma primary cutaneous T-cell lymphoma primary cutaneous T-cell non-Hodgkin lymphoma Sezary syndrome subcutaneous panniculitis-like T-cell lymphoma systemic Epstein-Barr virus-positive T-cell lymphoproliferative disease of childhood T-cell large granular lymphocyte leukemia T-cell non-Hodgkin lymphoma T-cell prolymphocytic leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Adult T-cell leukemia/lymphoma Aggressive NK-cell leukemia Anaplastic large cell lymphoma, ALK-negative Anaplastic large cell lymphoma, ALK-positive Angioimmunoblastic T-cell lymphoma Breast implant-associated anaplastic large cell lymphoma Chronic active EBV infection of T-and NK-cell type, systemic form Chronic lymphoproliferative disorder of NK cells Enteropathy-associated T-cell lymphoma Extranodal NK/T cell lymphoma, nasal type Follicular T-cell lymphoma Hepatosplenic T-cell lymphoma Hydroa vacciniforme-like lymphoproliferative disorder Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract Intestinal T-cell lymphoma, not otherwise specified Monomorphic epitheliotropic intestinal T-cell lymphoma Mycosis fungoides NK-cell lymphoma Nodal peripheral T-cell lymphoma with TFH phenotype Peripheral T-cell lymphoma, not otherwise specified Primary cutaneous acral CD8-positive T-cell lymphoma Primary cutaneous anaplastic large cell lymphoma Primary cutaneous CD8-positive aggressive epidermotropic T-cell lymphoma Primary cutaneous T-cell lymphoma Sezary syndrome Subcutaneous panniculitis-like T-cell lymphoma Systemic Epstein Barr virus positive T-cell lymphoproliferative disease of childhood Systemic Epstein-Barr virus positive T-cell lymphoproliferative disease of childhood (disorder) T-cell large granular lymphocytic leukemia T-cell lymphoma T-cell prolymphocytic leukemia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    26 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • City of Hope Cancer Center (Data collection only)

    NOT_YET_RECRUITING

    Duarte, California, 91010, United States

  • Dana Farber Cancer Institute (Data Collection Only)

    NOT_YET_RECRUITING

    Boston, Massachusetts, 02115, United States

  • Emory University (Data Collection Only)

    NOT_YET_RECRUITING

    Atlanta, Georgia, 30322, United States

  • MD Anderson Cancer Center (Data Collection Only)

    NOT_YET_RECRUITING

    Houston, Texas, 77030, United States

  • Massachusetts General Hospital (Data Collection Only)

    NOT_YET_RECRUITING

    Boston, Massachusetts, 02114, United States

  • Mayo Clinic (Data Collection Only)

    NOT_YET_RECRUITING

    Rochester, Minnesota, 55905, United States

  • Memorial Sloan Kettering Cancer Center (All Protocol Activities)

    RECRUITING

    New York, New York, 10065, United States

  • Memorial Sloan Kettering Cancer Center @ Suffolk-Commack (All protocol activities)

    RECRUITING

    Commack, New York, 11725, United States

  • Memorial Sloan Kettering Monmouth (All protocol activities)

    RECRUITING

    Middletown, New Jersey, 07748, United States

  • Memorial Sloan Kettering Nassau (All protocol activities)

    RECRUITING

    Uniondale, New York, 11553, United States

  • Memorial Sloan Kettering Westchester (All protocol activities)

    RECRUITING

    Harrison, New York, 10604, United States

  • Memorial Sloan Kettering at Basking Ridge (All protocol activities)

    RECRUITING

    Basking Ridge, New Jersey, 07920, United States

  • Moffitt Cancer Center (Data Collection Only)

    NOT_YET_RECRUITING

    Tampa, Florida, 33612, United States

  • Northwestern Medicine (Data Collection)

    NOT_YET_RECRUITING

    Chicago, Illinois, 60611, United States

  • Ohio State University (Data Collection Only)

    NOT_YET_RECRUITING

    Columbus, Ohio, 43210, United States

  • Stanford University Medical Center (Data collection only)

    NOT_YET_RECRUITING

    Stanford, California, 94305-5408, United States

  • Thomas Jefferson University Hospital (Data collection only)

    NOT_YET_RECRUITING

    Philadelphia, Pennsylvania, 19107, United States

  • UNIVERSITY OF CALIFORNIA SAN DIEGO (Data collection only)

    NOT_YET_RECRUITING

    San Diego, California, 92103, United States

  • University of California San Francisco (Data collection only)

    NOT_YET_RECRUITING

    San Francisco, California, 94143, United States

  • University of Colorado (Data Collection Only)

    NOT_YET_RECRUITING

    Aurora, Colorado, 80045, United States

  • University of Miami (Data Collection Only)

    NOT_YET_RECRUITING

    Miami, Florida, 33136, United States

  • University of Nebraska (Data collection only)

    NOT_YET_RECRUITING

    Omaha, Nebraska, 68198-7680, United States

  • University of Pennsylvania (Data Collection Only)

    NOT_YET_RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

  • Washington University (Data Collection Only)

    NOT_YET_RECRUITING

    St Louis, Missouri, 63110, United States

  • Weill Cornell Medical Center (Data Collection Only)

    NOT_YET_RECRUITING

    New York, New York, 10021, United States

  • Yale University (Data Collection Only)

    NOT_YET_RECRUITING

    New Haven, Connecticut, 06511, United States

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