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New hope for rare childhood cancer: drug cocktail aims to shrink tumors and prevent return

NCT ID NCT06239272

Recruiting now Disease control Sponsor: St. Jude Children's Research Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 04, 2026 · Updated 4 times

Summary

This study is for children and young adults (up to age 30) with a rare type of soft tissue cancer called non-rhabdomyosarcoma. It tests whether adding the drugs pazopanib and selinexor to standard chemotherapy can improve outcomes. Participants receive treatment tailored to their risk level, and some also get targeted radiation. The goal is to control the disease and prevent it from coming back.

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Conditions

The condition(s) this trial relates to.

angiosarcoma clear cell sarcoma cutaneous undifferentiated pleomorphic sarcoma dedifferentiated liposarcoma dermatofibrosarcoma protuberans disorder of sexual differentiation epithelioid hemangioendothelioma epithelioid sarcoma extraosseous osteosarcoma extraskeletal myxoid chondrosarcoma fibrosarcoma giant cell tumor of soft tissue glomus tumor granular cell cancer granular cell tumor histiocytoma, Angiomatoid fibrous inflammatory leiomyosarcoma inflammatory myofibroblastic tumor intimal sarcoma leiomyosarcoma liposarcoma low grade fibromyxoid sarcoma malignant giant cell tumor of soft parts malignant melanocytic neoplasm of the peripheral nerve sheath malignant myoepithelioma malignant perineurioma malignant peripheral nerve sheath tumor malignant tenosynovial giant cell tumor myoepithelial tumor myxofibrosarcoma myxoid liposarcoma neoplasm with perivascular epithelioid cell differentiation Neoplasms, Adipose Tissue nerve sheath neoplasm neurofibrosarcoma ossifying fibromyxoid tumor osteosarcoma phosphaturic mesenchymal tumor pleomorphic liposarcoma sarcoma smooth muscle tumor soft tissue sarcoma solitary fibrous tumor synovial sarcoma tumor of adipose tissue undifferentiated (embryonal) sarcoma undifferentiated pleomorphic sarcoma undifferentiated round cell sarcoma well-differentiated liposarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADIPOCYTIC NEOPLASM ANGIOMATOID FIBROUS HISTIOCYTOMA ANGIOSARCOMA ATYPICAL FIBROXANTHOMA CLEAR CELL SARCOMA DEDIFFERENTIATED LIPOSARCOMA DERMATOFIBROSARCOMA PROTUBERANS, FIBROSARCOMATOUS EPITHELIOID HEMANGIOENDOTHELIOMA EPITHELIOID SARCOMA EXTRASKELETAL MYXOID CHONDROSARCOMA FIBROSARCOMA NOS GIANT CELL TUMOR OF SOFT PARTS NOS GLOMUS TUMOR GRANULAR CELL TUMOR, MALIGNANT INFLAMMATORY LEIOMYOSARCOMA INTIMAL SARCOMA LEIOMYOSARCOMA LIPOSARCOMA LOW GRADE FIBROMYXOID SARCOMA LOW GRADE MYOFIBROBLASTIC SARCOMA MALIGNANT PERIPHERAL NERVE SHEATH TUMOR MALIGNANT TENOSYNOVIAL GIANT CELL TUMOR OF SOFT TISSUE MELANOTIC MALIGNANT NERVE SHEATH TUMOR MYOEPITHELIAL CARCINOMA MYOEPITHELIOMA MYXOFIBROSARCOMA MYXOID LIPOSARCOMA MYXOID PLEOMORPHIC LIPOSARCOMA NTRK-REARRANGED SPINDLE CELL NEOPLASM OSSIFYING FIBROMYXOID TUMOR, MALIGNANT OSTEOSARCOMA, EXTRASKELETAL PERINEURIOMA, MALIGNANT PERIVASCULAR EPITHELIOID TUMOR, MALIGNANT PHOSPHATURIC MESENCHYMAL TUMOR, MALIGNANT PLEOMORPHIC LIPOSARCOMA PLEOMORPHIC SARCOMA, UNDIFFERENTIATED ROUND CELL SARCOMA ROUND CELL SARCOMA, UNDIFFERENTIATED SCLEROSING EPITHELIOID FIBROSARCOMA SYNOVIAL SARCOMA UNDIFFERENTIATED SARCOMA WELL DIFFERENTIATED LIPOSARCOMA

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Children's Healthcare of Atlanta

    RECRUITING

    Atlanta, Georgia, 30329, United States

  • Cincinnati Children's Hospital Medical Center

    RECRUITING

    Cincinnati, Ohio, 45229, United States

  • Dana Farber Cancer Institute

    RECRUITING

    Boston, Massachusetts, 02215, United States

  • Lurie Children's Hospital of Chicago

    RECRUITING

    Chicago, Illinois, 60611, United States

  • Our Lady of the Lake Children's Hospital

    RECRUITING

    Baton Rouge, Louisiana, 70809, United States

  • St. Jude Children's Research Hospital

    RECRUITING

    Memphis, Tennessee, 38105, United States

    Contact Email: •••••@•••••

  • Washington University Medical Center

    RECRUITING

    St Louis, Missouri, 63110, United States

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