Could a genetic marker guide future cancer therapies in taiwan?
NCT ID NCT06665776
First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time
Summary
This study is measuring how often a specific genetic marker (HLA-A*02:01) and a cancer-related protein (NY-ESO-1) appear in Taiwanese patients with solid tumors like head and neck, liver, lung, breast, and esophageal cancers. By understanding these frequencies, researchers hope to identify which patients might benefit from future targeted immunotherapies. The study involves collecting blood and tumor tissue samples from about 485 participants.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If certain markers are common, this could help design targeted immunotherapies for Taiwanese cancer patients.
- What could go wrong
- This is an observational study only—it does not test any treatment. The findings may not lead to new therapies.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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485 people
The number who actually took part.
- Started
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Mar 2023
- Finished
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May 2026
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Adult patients with confirmed diagnosis of any of the following solid tumor: 1. Head and neck squamous cell carcinoma, excluding nasopharyngeal carcinoma; 2. Hepatocellular carcinoma; 3. Lung squamous cell carcinoma; 4. Synovial sarcoma; 5. Triple-negative breast cancer; 6. Esophageal squamous cell carcinoma; 7. Cervical cancer; 8. Ovarian cancer
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Able to understand and voluntarily sign an informed consent form (ICF). 2. Adult aged ≥ 18 years at the time of informed consent (or other age required by local regulations). 3. Confirmed diagnosis of any of the following solid tumor: 1. Head and neck squamous cell carcinoma, excluding nasopharyngeal carcinoma; 2. Hepatocellular carcinoma; 3. Lung squamous cell carcinoma; 4. Synovial sarcoma; 5. Triple-negative breast cancer; 6. Esophageal squamous cell carcinoma; 7. Cervical cancer; 8. Ovarian cancer 4. Patient who received standard curative or palliative therapy including but not limited to any targeted therapy based on mutation status for their cancer, or patient with advanced solid tumors for which there is no accepted therapy, standard therapies are no longer effective, or the patient refuses additional standard therapy. 5. Eastern Cooperative Oncology Group (ECOG) Performance Status ≤1. 6. Body weight ≥ 50 Kg. 7. Life expectancy of ≥ 6 months. 8. Patient who agrees to provide the tumor sample for NY-ESO-1 IHC staining, from either fresh or archival tissue Exclusion Criteria: 1. Known primary immunodeficiency (such as Severe Combined Immunodeficiency Disease or AIDS). 2. Uncontrolled intercurrent illness which is not suitable for enrollment at the discretion of the investigator, including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, unstable cardiac arrhythmia, psychiatric illness, or social situations that would limit compliance with study requirements. 3. Currently confirmed diagnosis of at least 2 active cancers; patient who was cured of the other cancer \[disease free period \> 6 months\] and currently has only one research targeted tumor can be enrolled. 4. Untreated or symptomatic brain metastasis. 5. History of organ transplantation or allogeneic stem cell transplantation. 6. Other conditions (e.g. previous use of any cell therapy) which are not suitable for enrollment at the discretion of the investigator.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Chang Gung Memorial Hospital, Chiayi Branch
Chiayi City, Taiwan, Taiwan
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National Cheng Kung University Hospital
Tainan, Taiwan, 704, Taiwan
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National Taiwan University Hospital
Taipei, Taiwan, Taiwan
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Taichung Veterans General Hospital
Taichung, Taiwan, 407219, Taiwan
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Taipei Medical University Hospital
Taipei, Taiwan, Taiwan
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Taipei Veterans General Hospital
Taipei, Taiwan, 11217, Taiwan
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Other studies related to the condition(s) this trial covers.
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