Could a genetic marker guide future cancer therapies in taiwan?

NCT ID NCT06665776

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time

Summary

This study is measuring how often a specific genetic marker (HLA-A*02:01) and a cancer-related protein (NY-ESO-1) appear in Taiwanese patients with solid tumors like head and neck, liver, lung, breast, and esophageal cancers. By understanding these frequencies, researchers hope to identify which patients might benefit from future targeted immunotherapies. The study involves collecting blood and tumor tissue samples from about 485 participants.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If certain markers are common, this could help design targeted immunotherapies for Taiwanese cancer patients.
What could go wrong
This is an observational study only—it does not test any treatment. The findings may not lead to new therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

485 people

The number who actually took part.

Started

Mar 2023

Finished

May 2026

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients with confirmed diagnosis of any of the following solid tumor: 1. Head and neck squamous cell carcinoma, excluding nasopharyngeal carcinoma; 2. Hepatocellular carcinoma; 3. Lung squamous cell carcinoma; 4. Synovial sarcoma; 5. Triple-negative breast cancer; 6. Esophageal squamous cell carcinoma; 7. Cervical cancer; 8. Ovarian cancer

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Able to understand and voluntarily sign an informed consent form (ICF). 2. Adult aged ≥ 18 years at the time of informed consent (or other age required by local regulations). 3. Confirmed diagnosis of any of the following solid tumor: 1. Head and neck squamous cell carcinoma, excluding nasopharyngeal carcinoma; 2. Hepatocellular carcinoma; 3. Lung squamous cell carcinoma; 4. Synovial sarcoma; 5. Triple-negative breast cancer; 6. Esophageal squamous cell carcinoma; 7. Cervical cancer; 8. Ovarian cancer 4. Patient who received standard curative or palliative therapy including but not limited to any targeted therapy based on mutation status for their cancer, or patient with advanced solid tumors for which there is no accepted therapy, standard therapies are no longer effective, or the patient refuses additional standard therapy. 5. Eastern Cooperative Oncology Group (ECOG) Performance Status ≤1. 6. Body weight ≥ 50 Kg. 7. Life expectancy of ≥ 6 months. 8. Patient who agrees to provide the tumor sample for NY-ESO-1 IHC staining, from either fresh or archival tissue Exclusion Criteria: 1. Known primary immunodeficiency (such as Severe Combined Immunodeficiency Disease or AIDS). 2. Uncontrolled intercurrent illness which is not suitable for enrollment at the discretion of the investigator, including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, unstable cardiac arrhythmia, psychiatric illness, or social situations that would limit compliance with study requirements. 3. Currently confirmed diagnosis of at least 2 active cancers; patient who was cured of the other cancer \[disease free period \> 6 months\] and currently has only one research targeted tumor can be enrolled. 4. Untreated or symptomatic brain metastasis. 5. History of organ transplantation or allogeneic stem cell transplantation. 6. Other conditions (e.g. previous use of any cell therapy) which are not suitable for enrollment at the discretion of the investigator.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Chang Gung Memorial Hospital, Chiayi Branch

    Chiayi City, Taiwan, Taiwan

  • National Cheng Kung University Hospital

    Tainan, Taiwan, 704, Taiwan

  • National Taiwan University Hospital

    Taipei, Taiwan, Taiwan

  • Taichung Veterans General Hospital

    Taichung, Taiwan, 407219, Taiwan

  • Taipei Medical University Hospital

    Taipei, Taiwan, Taiwan

  • Taipei Veterans General Hospital

    Taipei, Taiwan, 11217, Taiwan

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