Radiation or watchful waiting? new trial for aggressive skin cancer
NCT ID NCT06692556
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial compares two strategies for people with high-risk cutaneous squamous cell carcinoma after surgery: adding radiation therapy versus simply monitoring. About 266 participants will be randomly assigned to one of the two groups and followed for at least two years. The main goal is to see whether radiation improves disease-free survival.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
adjuvant radiotherapy
What this could lead to
If it works, this could show that adding radiation after surgery reduces the chance of cancer coming back in high-risk patients.
What could go wrong
This is a phase 3 trial, but it's still possible that radiation offers no benefit over monitoring, or that side effects outweigh any gain. Results may not apply to all patients.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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CHU de Bordeaux - Hôpital Saint André
NOT_YET_RECRUITINGBordeaux, New Aquitaine, 33076, France
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Contact
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Centre Antoine Lacassagne
NOT_YET_RECRUITINGNice, Provence-Alpes-Côte d'Azur Region, 06189, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centre De Radiothérapie Guillaume Le Conquérant
NOT_YET_RECRUITINGLe Havre, Normandy, 76600, France
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centre Georges François Leclerc
ACTIVE_NOT_RECRUITINGDijon, Bourgogne-Franche-Comté, 21079, France
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Centre Hospitalier Annecy Genevois
RECRUITINGMetz-Tessy, Haute-Savoie, 74374, France
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centre Hospitalier Emile Roux
WITHDRAWNLe Puy-en-Velay, Auvergne-Rhône-Alpes, 43000, France
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Centre Hospitalier Romans - Hopitaux Drôme Nord
RECRUITINGRomans-sur-Isère, Drôme, 26102, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centre Hospitalier Régional Universitaire de Brest - Hôpital Morvan
WITHDRAWNBrest, Finistère, 29200, France
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Centre Hospitalier Simone Veil de Blois
RECRUITINGBlois, Loir-et-Cher, 41016, France
Contact Email: •••••@•••••
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Centre Hospitalier Universitaire Amiens-Picardie
ACTIVE_NOT_RECRUITINGAmiens, Somme, 80054, France
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Centre Hospitalier Universitaire Estaing
RECRUITINGClermont-Ferrand, Puy-de-Dôme, 63033, France
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centre Hospitalier Universitaire Rouen - Hôpital Charles Nicolle
NOT_YET_RECRUITINGRouen, Seine-Maritime, 76031, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centre Hospitalier Universitaire de Bordeaux
ACTIVE_NOT_RECRUITINGPessac, Gironde, 33604, France
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Centre Hospitalier Universitaire de Grenoble-Alpes
NOT_YET_RECRUITINGLa Tronche, Isère, 38700, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centre Hospitalier Universitaire de Nantes - Hôtel-Dieu
RECRUITINGNantes, Loire-Atlantique, 44093, France
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Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centre Hospitalier Universitaire de Rennes
NOT_YET_RECRUITINGRennes, Ille-et-Vilaine, 35033, France
Contact Email: •••••@•••••
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Centre Hospitalier Universitaire de Saint-Etienne - Hôpital Nord
RECRUITINGSaint Priest En Jarez, Pays de la Loire Region, 42271, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centre Hospitalier de Valence
RECRUITINGValence, Drôme, 26000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centre Léon Bérard
RECRUITINGLyon, 69373, France
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centre de Radiothérapie Marie Curie
NOT_YET_RECRUITINGValence, Drôme, 26000, France
Contact Email: •••••@•••••
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Centre hospitalier de Roanne
RECRUITINGRoanne, Pays de la Loire Region, 42300, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Groupe Hospitalier Bretagne Sud
RECRUITINGLorient, Morbihan, 56322, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospices Civils de Lyon - Centre Hospitalier Lyon Sud
NOT_YET_RECRUITINGPierre-Bénite, Auvergne-Rhône-Alpes, 69495, France
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital Bichat Claude-Bernard
ACTIVE_NOT_RECRUITINGParis, Île-de-France Region, 75877, France
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Hôpital d'instruction des armées Sainte-Anne
WITHDRAWNToulon, Var, 83800, France
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Hôpital de la Cavale Blanche
NOT_YET_RECRUITINGBrest, Finistère, 29200, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Institut Godinot
ACTIVE_NOT_RECRUITINGReims, Marne, 51726, France
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Institut de Cancérologie de Lorraine
RECRUITINGVandœuvre-lès-Nancy, MMeurthe-et-Moselle, 54519, France
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact