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Could a 2-Week radiation course replace longer treatment for skin cancer?

NCT ID NCT06998342

Recruiting now Disease control Sponsor: University of Vermont Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a short course of radiation (5 treatments over 2 weeks) can prevent cancer from coming back in people with high-risk head and neck skin cancer after surgery. For those with moderate-risk cancer, researchers want to see if simply monitoring them closely is safe instead of giving radiation. The trial will enroll 24 adults and follow them for 2 years to check for recurrence.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Short-course radiation therapy (5 treatments over 2 weeks)
What this could lead to
If successful, this could offer a shorter, more convenient radiation option for high-risk skin cancer and show that some patients can safely skip radiation altogether.
What could go wrong
This is a small, early-phase pilot study with only 24 participants, so results may not apply broadly. The active surveillance approach carries a risk of cancer returning without immediate treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Head and Neck Neoplasms skin squamous cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CUTANEOUS SQUAMOUS CELL CARCINOMA (CSCC)

Contacts and locations

Locations

  • University of Vermont Medical Center

    RECRUITING

    Burlington, Vermont, 05401, United States

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