CUTANEOUS SQUAMOUS CELL CARCINOMA (CSCC)

This study tests whether injecting the drug cemiplimab directly into early-stage skin cancer tumors can work as well as surgery to remove them. About 369 adults with a type of skin cancer called cutaneous squamous cell carcinoma will be randomly assigned to get either the injecti…

This study tests whether adding radiation therapy after surgery helps prevent high-risk skin cancer from returning, compared to just monitoring. About 266 adults with completely removed, high-risk squamous cell carcinoma will be randomly assigned to receive radiation or regular c…

This early-phase study tests a new experimental treatment called VET3-TGI, a virus designed to attack cancer cells. It is given alone or with an immunotherapy drug (atezolizumab) to about 60 adults with advanced solid tumors that have not responded to standard treatments. The mai…

This study aims to find biological markers in blood and tumor tissue that can predict whether a patient with cutaneous squamous cell carcinoma will respond to the immunotherapy drug cemiplimab or experience side effects. Researchers will enroll 30 adults and use advanced flow cyt…

This study looks at blood samples from 20 adults with melanoma or other skin cancers to see if certain markers in the blood can predict how well treatment works or how long people live. Participants give blood during their regular care. The goal is to find better ways to monitor …

This study is for people with a common type of skin cancer called cutaneous squamous cell carcinoma. Before their scheduled surgery to remove the tumor, they will receive a flu shot injected directly into the cancer. The goal is to see if this can activate immune cells to better …

This study looks at whether a blood test that finds tiny bits of tumor DNA (called ctDNA) can tell if head and neck cancer has returned after successful treatment. Researchers will follow 250 adults who have finished curative surgery or radiation. The goal is to see if a positive…