Could a shot replace the knife for skin cancer?

NCT ID NCT06585410

Recruiting now Disease control Sponsor: Regeneron Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 01, 2026 · Updated 3 times

Summary

This phase 3 trial tests whether injecting the drug cemiplimab directly into early-stage skin cancer tumors can work as well as surgery. About 369 people with small tumors on the head, neck, hand, or shin will be randomly assigned to get either the injections or standard surgery. The study will compare how long people stay cancer-free and track side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

cemiplimab (Libtayo)

What this could lead to

If it works, this could offer a non-surgical option for early-stage skin cancer, potentially avoiding scars and recovery time.

What could go wrong

This is still experimental; cemiplimab may not work as well as surgery, and side effects from immune activation can occur. The trial is also limited to specific tumor sizes and locations.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

skin neoplasm skin squamous cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CUTANEOUS SQUAMOUS CELL CARCINOMA (CSCC)

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Arkansas Research Trials
RECRUITING

North Little Rock, Arkansas, 72117, United States
Buckeye Dermatology - Springfield Office
RECRUITING

Springfield, Ohio, 45505, United States
Center for Clinical Studies at Webster Clear Lake
RECRUITING

Webster, Texas, 77598, United States
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Clinical Research Center of the Carolinas
RECRUITING

Charleston, South Carolina, 29407, United States
Columbia University Medical Center - Herbert Irving Center for Dermatology and Skin Cancer - Herbert Irving Pavilion
RECRUITING

New York, New York, 10032, United States
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Dawes Fretzin Clinical Research - Shadeland Ave.
WITHDRAWN

Indianapolis, Indiana, 46250, United States
Dermatology Associates of the Palm Beaches, Integri Research at Dermatology Associates
RECRUITING

Delray Beach, Florida, 33445, United States
Dermatology Health Specialists
RECRUITING

Bend, Oregon, 97702, United States
Dermatology Institute of Victoria (DIV)
RECRUITING

South Yarra, Victoria, 3141, Australia
Dermatology and Skin Cancer Center
RECRUITING

Lee's Summit, Missouri, 64064, United States
Epiphany Dermatology
RECRUITING

Lewisville, Texas, 75056, United States
Equity Medical, LLC
WITHDRAWN

Bowling Green, Kentucky, 42104, United States
Fremantle Dermatology
RECRUITING

Fremantle, Western Australia, 6160, Australia
George Washington University Medical Faculty Associates
RECRUITING

Washington D.C., District of Columbia, 20037, United States
Hospital of the University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Las Vegas Dermatology
RECRUITING

Las Vegas, Nevada, 89144, United States
Life Clinical Trials
RECRUITING

Coral Springs, Florida, 33071, United States
Mayo Clinic - Arizona
RECRUITING

Scottsdale, Arizona, 85259, United States
Medical Dermatology Specialists - Phoenix
RECRUITING

Phoenix, Arizona, 85006, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10021, United States
Metropolitan Dermatology
WITHDRAWN

Clark, New Jersey, 07066, United States
MyMichigan Dermatologic Oncology
RECRUITING

Midland, Michigan, 48640, United States
Northeast Dermatology Associates
RECRUITING

Beverly, Massachusetts, 01915, United States
Oak Dermatology
RECRUITING

Naperville, Illinois, 60563, United States
Oregon Health & Science University
RECRUITING

Portland, Oregon, 97239, United States
Peak Dermatology, Aesthetics and Wellness
RECRUITING

Visalia, California, 93291, United States
Penn State Hershey Medical Center
RECRUITING

Hershey, Pennsylvania, 17033, United States
Princess Alexandra Hospital
RECRUITING

Woolloongabba, Queensland, 4102, Australia
Profound Research, Dermatology Medical Group - Oceanside
RECRUITING

Oceanside, California, 92056, United States
Reveal Research Institute
RECRUITING

Dallas, Texas, 75235, United States
Rochester Dermatologic Surgery, P.C.
RECRUITING

Victor, New York, 14564, United States
Somerset Skin Centre
RECRUITING

Troy, Michigan, 48084, United States
Stanford University
RECRUITING

Redwood City, California, 94063, United States
StracSkin, PLLC
RECRUITING

Portsmouth, New Hampshire, 03801, United States
Texas Dermatology and Laser Specialists
RECRUITING

San Antonio, Texas, 78218, United States
The Skin Hospital
RECRUITING

Darlinghurst, New South Wales, 2010, Australia
The University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
The University of Texas at Austin Dell Medical School Ascension Medical Group
RECRUITING

Austin, Texas, 78701, United States
UC San Diego Moores Cancer Center
RECRUITING

La Jolla, California, 92093, United States
UNC Hospitals Dermatology and Skin Cancer Center at Southern Village
RECRUITING

Chapel Hill, North Carolina, 27516, United States
US Dermatology Partners DBA DermAssociates, PC
RECRUITING

Rockville, Maryland, 20850, United States
University of Arizona Cancer Center
RECRUITING

Tucson, Arizona, 85719, United States
University of Chicago Medical Center
RECRUITING

Chicago, Illinois, 60637, United States
University of New Mexico
RECRUITING

Albuquerque, New Mexico, 87102, United States
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of South Florida
RECRUITING

Tampa, Florida, 33612, United States
University of Utah Hospital
RECRUITING

Salt Lake City, Utah, 84132, United States
Vcu Massey Cancer Center
RECRUITING

Richmond, Virginia, 23298, United States
Washington University in St. Louis - Center for Dermatologic and Cosmetic Surgery
RECRUITING

St Louis, Missouri, 63141, United States
Westmead Hospital
RECRUITING

Westmead, New South Wales, 2145, Australia