Laser and steroid mouthwash aim to tame painful mouth sores in autoimmune disease

This study tests whether a steroid mouthwash (clobetasol propionate 0.05%) and low-level laser therapy, alone or together, can heal painful mouth sores in people with pemphigus vulgaris—a chronic autoimmune disease that causes blisters on skin and mucous membranes. Thirty participants with active oral lesions will be randomly assigned to one of three groups: mouthwash only, laser only, or both. The goal is to see if these topical treatments can reduce lesion severity and pain, potentially allowing patients to lower their systemic steroid doses and avoid long-term side effects.