Laser and steroid mouthwash aim to tame painful mouth sores in autoimmune disease
NCT ID NCT07641725
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a steroid mouthwash (clobetasol propionate 0.05%) and low-level laser therapy, alone or together, can heal painful mouth sores in people with pemphigus vulgaris—a chronic autoimmune disease that causes blisters on skin and mucous membranes. Thirty participants with active oral lesions will be randomly assigned to one of three groups: mouthwash only, laser only, or both. The goal is to see if these topical treatments can reduce lesion severity and pain, potentially allowing patients to lower their systemic steroid doses and avoid long-term side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
clobetasol propionate 0.05% mouthwash and photobiomodulation (low-level laser therapy)
What this could lead to
If effective, these topical treatments could speed healing of oral lesions and allow patients to lower their steroid doses, reducing long-term side effects.
What could go wrong
This is a small, early-stage study with only 30 participants, so results may not apply broadly. The treatments are supportive, not a replacement for systemic therapy.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Department of Oral Medicine, Faculty of Dental medicine
RECRUITINGDamascus, Syria
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact