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Could a stool transplant ease gut woes in scleroderma?

NCT ID NCT06827977

Recruiting now Disease control Sponsor: The University of Texas Health Science Center, Houston Source: ClinicalTrials.gov ↗

First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time

Summary

This study tests whether transplanting healthy gut bacteria can relieve constipation and bloating in people with systemic sclerosis, an autoimmune disease that often affects the digestive tract. Participants will receive the bacteria either as capsules or as a retention enema. The trial will monitor changes in gut bacteria diversity and symptom severity over several weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
PRIM-DJ2727 (frozen or lyophilized fecal microbiota)
What this could lead to
If it works, this could offer a new way to manage stubborn digestive symptoms in people with systemic sclerosis.
What could go wrong
This is a small, early-phase trial testing safety and trends, not proof of effectiveness. The treatment involves swallowing capsules or receiving an enema made from donor stool, which carries unknown infection risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

constipation disorder systemic sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BLOATING CONSTIPATION

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • The University of Texas Health Science Center at Houston

    RECRUITING

    Houston, Texas, 77030, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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