CONSTIPATION

This study looks at whether a new high-resolution probe can better diagnose severe constipation that doesn't get better with standard laxatives. Researchers will compare 76 healthy volunteers and patients with suspected colonic inertia. The goal is to see if the new probe gives c…

This study tests an experimental drug called brenipatide for adults with irritable bowel syndrome with constipation (IBS-C). About 342 participants will receive either the drug or a placebo injection under the skin for several weeks. The goal is to see if the drug safely improves…

This study tests whether a daily probiotic drop (BioAmicus Complete) can ease tummy issues like colic, constipation, and diarrhea, as well as skin symptoms of food allergy (eczema) in infants. About 140 babies will receive either the probiotic or a placebo for 25 days. The goal i…

This study looks at two different bowel treatments—oral senna or a rectal suppository—to see which helps women have their first bowel movement sooner after vaginal surgery for pelvic organ prolapse. About 88 women will take part, and their satisfaction with the treatment will als…

This study looks at whether a fermented milk drink containing a specific probiotic (Lacticaseibacillus paracasei strain Shirota) can help relieve constipation symptoms in Filipino adults. Researchers will measure changes in stool consistency, bowel movement frequency, and how lon…

This study tests whether an herbal formula called MZRW can help cancer survivors who have constipation. About 70 adults who have finished cancer treatment at least a month ago will take either MZRW or a placebo pill for 2 weeks. Researchers will check if bowel movements improve a…

This study tests whether a probiotic supplement (Lactobacillus plantarum) can safely improve bowel habits in adults with chronic constipation. About 80 participants will receive either the probiotic or a placebo. The main goal is to see if stool consistency shifts from hard to no…

This study looks at whether a natural dietary supplement called Inno Cleanse can help reduce bloating in healthy people who often feel bloated. Researchers will give 30 participants either the supplement or a placebo for two weeks and track changes in bloating, weight, and other …

This study tests whether pyridostigmine, a drug that boosts nerve signals, can help with constipation in people with Parkinson disease. Constipation is a common and frustrating symptom that often starts years before movement problems. The trial will measure changes in bowel movem…

This study from Mayo Clinic aims to better understand a type of constipation called dyssynergic defecation, where the muscles don't work together properly during a bowel movement. Researchers will test improved biofeedback treatments to help people retrain those muscles. The stud…

This study tests tenapanor, a drug already approved for irritable bowel syndrome with constipation, in 25 adults with cystic fibrosis who also have constipation. Participants take one 50 mg tablet twice daily for 4 weeks and fill out questionnaires and daily diaries to track bowe…

This study tests a liquid probiotic with multiple bacterial strains in 20 adults who have constipation. Participants stop other constipation treatments and take the probiotic for several weeks. The goal is to see if it improves symptoms like bloating and bowel habits, and boosts …

This study tests whether taking a daily probiotic called Weizmannia (Bacillus) coagulans JBI-YZ6.3 can ease constipation and improve overall gut health in healthy, physically active adults aged 18 to 50. About 30 participants will receive both the probiotic and a placebo at diffe…

This study tests a new device called Fecobionics to better understand constipation caused by pelvic floor dyssynergia. Researchers will use the device to measure how the rectum and anus work during defecation in 24 adults. The goal is to see if these measurements can predict how …