CONSTIPATION

This study compared two surgical techniques for treating Hirschsprung's disease in children: the traditional Soave method and a newer heart-shaped anastomosis. The trial involved 177 children under 14 years old across multiple hospitals. The goal was to see which approach leads t…

This study looked at 20 children with Hirschsprung disease, a condition where part of the bowel lacks nerve cells, causing severe constipation. Researchers compared two surgical methods—Swenson and Soave—to see which one had shorter operation time and better daily bowel movements…

This early study tested a wireless patch that uses a tiny electric current to push two drugs (neostigmine and glycopyrrolate) through the skin and into the blood. The goal is to help people with spinal cord injury have predictable bowel movements without needles. Only 2 healthy v…

This phase II trial tested the drug isatuximab in 43 patients with AL amyloidosis that had come back or stopped responding to treatment. Isatuximab is a monoclonal antibody that may help stop abnormal protein buildup. The study measured how well the drug reduced disease markers a…

This study tested a new device called MOWOOT for people with chronic constipation. 86 adults who already used standard treatment (trans-anal irrigation) tried the MOWOOT device to see if it improved their symptoms and quality of life. The goal was to compare the new device's effe…

This study tested health and wellness products to see if they could improve common stomach issues like gas, bloating, diarrhea, and constipation. About 500 adults from across the U.S. took part. Participants took either the product or a placebo (a dummy pill) and reported their s…

This study tested whether applying a magnetic field to the belly can reduce constipation severity. 75 adults with chronic constipation were split into three groups: one received active magnetic therapy twice a week for 8 weeks, one received a sham treatment (device on but no magn…

This study tested a low-volume irrigation device (Qufora IrriSedo MiniGo) in 92 adults with fecal incontinence, chronic constipation, or both. Participants used the device at home to see if it improved bowel function and daily life. The goal was to find a simple, non-drug option …

This study looked at whether giving people a gentle abdominal massage before surgery could help prevent constipation after the operation. Sixty adults who were already constipated and scheduled for general surgery took part. Half received a 15-minute massage twice a day before su…

This study looked at whether taking a laxative (polyethylene glycol 3350) both before and after surgery helps reduce discomfort during bowel movements after pelvic prolapse repair. 74 women having minimally invasive surgery were randomly assigned to take the laxative before and a…

This completed trial tested whether a nerve stimulation treatment called PTNS can help children aged 8-18 with constipation caused by pelvic floor dyssynergia. Forty participants received either real PTNS or a sham (fake) treatment to see if it improves bowel function. The goal i…

This study tested whether abdominal massage can relieve constipation in people receiving hemodialysis. 49 adults took part. Researchers measured changes in constipation severity, quality of life, and stool consistency. The goal was to see if this simple, noninvasive technique cou…

This study tested whether daily probiotic supplements could improve constipation and weight gain in 30 children with cerebral palsy. Participants took either Lactobacillus reuteri or a prebiotic-enriched Lactobacillus rhamnosus for 28 days. Caregivers tracked bowel movements and …

This study looked at whether one session of abdominal massage can improve blood vessel stiffness, muscle oxygen levels, and exercise ability in adults with chronic constipation. About 30 people took part, with some getting a real massage and others resting instead. Researchers me…

This study tested whether a special 'constipation insole' based on reflexology could help ease constipation in 139 adults receiving palliative care. Participants in the experimental group walked with the insole for 20 minutes daily for four weeks, while the control group walked t…

This study tested whether ear massage can help bowel activity return faster after lower extremity surgery. Forty patients were split into two groups: one received standard care plus ear massage twice daily, the other standard care alone. Researchers measured when bowel sounds ret…

This small pilot study looked at whether treating constipation with a common laxative (lactulose) is practical for people with chronic kidney disease. Fourteen participants took lactulose daily for up to 6 weeks. The main goal was to see if people would stick with the treatment a…

This study tested whether a telerehabilitation-based exercise program, along with a constipation education booklet, could reduce constipation symptoms and improve quality of life. Thirty-two adults with constipation took part. The approach used remote video sessions to guide exer…

This study tested whether a daily probiotic called Weizmannia coagulans BC99 can improve chronic constipation. 90 adults with constipation took either the probiotic or a placebo for a period, and researchers tracked changes in stool form and gut bacteria. The goal was to see if t…

This study developed a risk assessment scale to identify hospitalized patients likely to develop constipation. Researchers enrolled 516 adults staying at least 4 days in the hospital. The goal is to catch high-risk individuals early and start prevention measures.

This study looked at how fermented dairy (like yogurt) and non-fermented dairy (like milk) affect bowel habits and thinking skills in healthy women who have bowel movements every other day or less. 96 women took part, eating 300g of dairy daily for 4 weeks. The goal was to see if…

This early-stage study tested a single dose of TD-1211, an experimental drug for constipation, in 47 healthy adults split into younger (18-45) and older (65-85) groups. Researchers measured how the body absorbs and eliminates the drug and checked for side effects. The goal was to…

This study tested a new, faster care plan for people with chronic constipation at a University of Michigan gastroenterology clinic. Researchers wanted to see how often doctors ordered special tests and pelvic floor therapy, and how satisfied patients were with their care. The stu…

This study tested a new device called Fecobionics, which acts like artificial stool, to better understand and diagnose chronic constipation and fecal incontinence. Researchers studied 236 people, including patients and healthy volunteers, to see if the device can provide clearer …

This study measured levels of the laxative PEG 3350 and its breakdown products in the blood and urine of 158 children who were already taking it, compared to children not taking it. The goal was simply to learn how the body processes this medicine, not to change any treatments. R…

This early-phase trial in 13 healthy volunteers measures how two drugs, neostigmine and glycopyrrolate, enter the bloodstream when given through a skin patch using a mild electric current (iontophoresis) compared to an IV. The goal is to see if this needle-free method could one d…