Gut bacteria may hold the key to constipation relief

NCT ID NCT06637397

Completed Symptom relief Sponsor: Wecare Probiotics Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This trial tests whether a daily probiotic called Weizmannia coagulans BC99 can relieve chronic constipation in adults. One hundred participants will receive either the probiotic or a placebo for several weeks. Researchers will measure changes in stool consistency, gut bacteria, and markers of inflammation to see if the probiotic improves symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: a probiotic supplement called Weizmannia coagulans BC99
What this could lead to: If it works, this could offer a natural, side-effect-friendly option for managing chronic constipation without laxatives.
What could go wrong: This is a small, early-stage trial in Chinese adults only, so results may not apply to other groups. Probiotics affect people differently, and the benefit may be modest or no better than placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

constipation disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CONSTIPATION

Contacts and locations

Locations

Henan University of Science and Technology

Luoyang, Henan, 471000, China
The School of Food and Bioengineering, Henan University of Science and Technolog

Luoyang, Henan, 471000, China

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