Constipation disorder

This pilot study tests whether a fecal microbiota transplant (FMT) combined with a high-fiber diet can safely and effectively treat chronic constipation. Five adults with functional constipation will receive FMT via colonoscopy and take a dietary fiber supplement. Researchers wil…

This study will follow about 4,000 people who have received a fecal microbiota transplant (FMT) — a procedure that transfers gut bacteria from a healthy donor to restore balance in the gut. It aims to see how well FMT works over 3 months, 1 year, and 5 years for conditions like r…

This study looks at whether a new, high-resolution probe can better diagnose severe constipation that doesn't get better with standard laxatives. Researchers will compare results from healthy volunteers and patients with suspected colonic inertia. The goal is to improve diagnosis…

This study tests a new way to measure how fast food moves through the gut in children with chronic constipation or other bowel emptying disorders. Instead of X-rays, it uses a special light-based imaging technique (MSOT) combined with a safe dye (ICG) and MRI scans. The goal is t…

This study tests a simple, at-home video program that teaches people how to better control their anal and belly muscles to reduce accidental bowel leaks and improve constipation. About 96 adults with these issues will either use the video exercises or take a placebo pill. The goa…

This study tests whether a personalized diet plan from a registered dietitian can improve constipation in people with Parkinson's disease. Fifty-four participants will follow the diet for 3 months, with regular check-ins. Researchers will measure bowel movements, gut bacteria, an…

This study tests whether combining repetitive transcranial magnetic stimulation (rTMS) with an anti-inflammatory diet can reduce constipation and improve quality of life in people with Crohn's disease. Fifty patients aged 40-60 will be split into two groups: one gets both rTMS an…

This study tests whether a probiotic supplement can safely relieve constipation in adults. About 105 people with chronic constipation will receive either the probiotic or a placebo. Researchers will track changes in stool consistency using the Bristol Stool Scale to see if the pr…

This study tests three doses of tenapanor (5, 25, or 50 mg twice daily) against a placebo in 692 adults with chronic idiopathic constipation. Over 26 weeks, researchers will check if the drug increases complete spontaneous bowel movements. The goal is to find a safe, effective op…

This study tests whether a traditional herbal formula called MZRW can help cancer survivors who suffer from constipation. Researchers will give 70 participants either MZRW or a placebo for two weeks and track bowel movements and gut bacteria changes. The goal is to see if MZRW is…

This study tests an injected drug called brenipatide in 342 adults with irritable bowel syndrome with constipation (IBS-C). Participants will receive either the drug or a placebo for about 35 weeks. The goal is to see if brenipatide safely reduces abdominal pain and improves bowe…

This study compares manual acupuncture and electroacupuncture to see which works better for people with long-term constipation. 72 adults will receive 12 weeks of treatment, three times per week. The main goal is to see if bowel movements increase to at least three per week. Rese…

This study tests whether a daily probiotic supplement called BioAmicus Complete can help infants with colic, constipation, diarrhea, and eczema. 140 babies will receive either the probiotic drops or a placebo (sunflower oil) for 25 days. Researchers will track changes in stool, c…

This study is testing a health and wellness product to see if it helps with digestion, constipation, and overall quality of life. It includes 133 adults in the U.S., some of whom are taking GLP-1 medications for weight loss. Participants will report their symptoms through surveys…

This study is testing whether a fermented milk drink containing a specific probiotic (Lacticaseibacillus paracasei strain Shirota) can help relieve constipation symptoms in Filipino adults. Researchers will measure changes in stool consistency, bowel movement frequency, and how l…

This study is testing a medicine called naldemedine to help children who get constipated from taking opioids (strong painkillers). About 24 children with cancer or other pain conditions will receive a single dose of the drug. Researchers will measure how the drug moves through th…

This pilot study tests whether Maralixibat, a drug that increases bile acids in the colon, can improve stool consistency in 20 children with cystic fibrosis who have chronic constipation. Participants will take the drug for two weeks alongside their usual laxatives. The goal is t…

This study looks at whether a device called Peristeen Light can improve bowel function in adults with fecal incontinence, chronic constipation, or who need a lot of time for bowel care. About 60 participants will use the device for 12 weeks. The goal is to see if it helps with bo…

This study is testing a treatment called sacral neuromodulation, which uses mild electrical pulses to stimulate nerves that control the bowel and bladder. The goal is to see if it can reduce symptoms like severe constipation, stomach pain, and loss of bowel control in children ag…

This study tests whether a popular dietary supplement called Inno Cleanse can reduce bloating in healthy adults who feel bloated often. Researchers will give 30 participants either the supplement or a placebo for two weeks and track changes in bloating, weight, and gut health. Th…

This study tests a new formula for treating constipation in children aged 6 months to 18 years. It compares the new formula to the standard treatment over 8 weeks, looking at how often children have bowel movements and how easy the medicine is to take. The goal is to find a bette…

This study tests whether taking psyllium or fructooligosaccharide (two types of fiber) for six days improves bowel function in women with constipation. Twenty-five women will try each fiber and a control, keeping a diary and having a scan to measure how fast food moves through th…

This study tests whether tenapanor, a drug already approved for irritable bowel syndrome with constipation, can help people with cystic fibrosis who have constipation. Twenty-five adults will take a 50 mg tablet twice daily for 4 weeks and track their bowel movements and symptoms…

This trial studies 88 women undergoing vaginal surgery for pelvic organ prolapse. Half will take senna pills and half will use bisacodyl suppositories after surgery. Researchers will measure how quickly each group has their first bowel movement and how satisfied they are with the…

This study tests whether pyridostigmine, a drug that stimulates the gut, can safely relieve chronic constipation in people with Parkinson's disease. Constipation is a common and bothersome symptom that often appears years before movement problems. Sixteen adults with Parkinson's …

This study tests whether a daily probiotic supplement (Weizmannia coagulans) can reduce constipation and improve gut health in healthy, physically active adults aged 18 to 50. About 30 participants will take the probiotic or a placebo for 4 weeks each, with a break in between, an…

This study looks at whether a special type of electronic moxibustion, based on the Ziwu Liuzhu theory, can help stroke patients who have constipation. Researchers will compare using this moxibustion alone versus combining it with ear acupressure. The goal is to see which approach…

This study is testing whether a supplement containing butyrate and polyphenols can improve gut health and reduce digestive discomfort like bloating, gas, and abdominal pain. Researchers will enroll 124 adults aged 25-70 who report regular gut issues. Participants will take either…

This study tests whether a probiotic called BioAmicus Complete can improve common stomach issues like colic, reflux, constipation, and diarrhea in infants up to 24 months old. About 110 babies will take the probiotic or receive standard care for 42 days. Parents will report sympt…

This study tests a device called MOWOOT that uses gentle pulses to help the colon move stool in adults with long-term constipation. About 40 people who are waiting for another treatment (trans-anal irrigation) will try the device daily for a period. The goal is to see if it impro…

This Phase 3 trial tests whether lubiprostone, a drug already used for other types of constipation, can safely increase bowel movements in people with slow transit constipation. About 346 adults will take either lubiprostone or a standard laxative (PEG) for 4 weeks. The main goal…

This trial tests whether a small device that stimulates a nerve in the ear (taVNS) can help people with constipation that hasn't improved with standard treatments. One hundred adults will be randomly assigned to receive either active or sham stimulation twice daily for 20 days. R…

This study tests whether a non-invasive brain stimulation technique called tACS can help people with severe constipation that hasn't improved with standard treatments, especially when they also have stress-related physical symptoms. About 60 adults will receive either real or sha…

This study tests a medicine called naldemedine for constipation caused by opioids (strong painkillers) in people with cancer. About 100 adults with cancer who take opioids and still have constipation despite laxatives will receive naldemedine. Researchers will measure how well it…

This study tests whether a daily capsule of ABKefir probiotics can improve constipation symptoms like bowel movement frequency and stool consistency. Researchers will compare ABKefir to a placebo over 8 weeks in 165 adults aged 18–75 with functional constipation. The goal is to s…

This pilot study is testing a multi-strain liquid probiotic in 20 adults who report having constipation. Participants take 70 ml of the probiotic daily for 28-35 days. The goal is to see if it improves constipation symptoms and quality of life, offering a possible alternative for…

This study at Mayo Clinic tests whether biofeedback therapy and inspiratory muscle training can help people with dyssynergic defecation—a condition where pelvic floor muscles don't relax properly during bowel movements. Two hundred adults aged 18 to 80 with chronic constipation w…

This study compares two treatments for abdominal pain in people with irritable bowel syndrome with constipation (IBS-C): a home-use device that delivers mild electrical stimulation (TEA) and the drug escitalopram (Lexapro). About 160 participants will be randomly assigned to one …

This study looks at whether different amounts of prune juice can help with constipation in older adults living in long-term care. 90 people aged 65 to 100 with constipation will drink 100, 150, or 200 mL of prune juice daily for 4 weeks. Researchers will track changes in stool co…

This study is looking at whether test anxiety during final exams is linked to bowel problems and constipation in university students. About 200 students will fill out questionnaires about their anxiety and digestive health. The goal is to better understand how mental stress might…

This study aims to collect medical data and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal diseases. Participants receive standard medical care at the NIH, and any extra samples or leftover tissue from procedu…

This study is creating a registry of up to 5,000 patients with various gut movement disorders, such as GERD, gastroparesis, and IBS. Doctors will use standard criteria to make accurate diagnoses and collect patient-reported outcomes. The goal is to improve understanding of these …

This study looks at whether using a squat toilet versus a sitting toilet affects ankle flexibility, leg strength, and constipation in school children aged 6 to 12. Researchers will measure ankle range of motion, leg power, and constipation symptoms in 191 kids from public and pri…

This study looks at how much of the constipation medicine prucalopride passes into breast milk. Researchers will collect milk samples from 12 women over 24 hours and track their babies' growth and any side effects for one year. The goal is to understand infant exposure, not to tr…

This study tests a new questionnaire that measures how well patients stick to a bowel management technique called transanal irrigation. The method helps people with bowel movement or leakage problems, but many stop using it over time. Researchers will enroll 100 adults who have u…

This study is following 2000 adults with functional digestive disorders like irritable bowel syndrome, dyspepsia, and constipation. Researchers will collect medical data and biological samples (biopsies, blood, urine, stool) during routine care. The goal is to find markers that c…

This study talks to parents of 12 to 15 children with functional constipation to learn about their experiences with physical activity. The goal is to understand if exercise might help, since there is little research on this topic. The results could lead to better care and possibl…

This study looks at the gut bacteria of 40 people with irritable bowel syndrome (IBS) who have constipation and produce high methane. Researchers will collect stool and blood samples to see which bacteria are present and how they change with standard treatment. The goal is to bet…

This study tests a new device called Fecobionics that measures how the rectum and anus work during bowel movements. Researchers want to see if it can predict which patients with a type of constipation called dyssynergia will benefit from biofeedback therapy. About 24 adults will …

This study is testing a new device called Fecobionics, which looks and feels like a normal stool, to better understand how people with chronic constipation defecate. Researchers will measure pressures and movements in the rectum and anal canal in 130 healthy volunteers and consti…