Could a bile acid blocker ease CF constipation?

NCT ID NCT06413368

Recruiting now Symptom relief Sponsor: Children's Hospital Los Angeles Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tests whether Maralixibat, a drug that increases bile acids in the colon, can improve stool consistency in 20 children with cystic fibrosis who have chronic constipation. Participants will take the drug for two weeks alongside their usual laxatives. The goal is to see if it helps soften stools and makes bowel movements easier.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Maralixibat (Livmarli)
What this could lead to: If it works, this could point toward a new treatment option for constipation in children with cystic fibrosis.
What could go wrong: This is a very small, early pilot study with only 20 participants and a short 2-week treatment period. Results may not apply to all patients, and the drug may not work better than standard laxatives.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

constipation disorder cystic fibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CONSTIPATION CHRONIC IDIOPATHIC CYSTIC FIBROSIS

Contacts and locations

Locations

Children's Hospital Los Angeles
RECRUITING

Los Angeles, California, 90027, United States

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