Could a bile acid blocker ease CF constipation?
NCT ID NCT06413368
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This pilot study tests whether Maralixibat, a drug that increases bile acids in the colon, can improve stool consistency in 20 children with cystic fibrosis who have chronic constipation. Participants will take the drug for two weeks alongside their usual laxatives. The goal is to see if it helps soften stools and makes bowel movements easier.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Maralixibat (Livmarli)
What this could lead to
If it works, this could point toward a new treatment option for constipation in children with cystic fibrosis.
What could go wrong
This is a very small, early pilot study with only 20 participants and a short 2-week treatment period. Results may not apply to all patients, and the drug may not work better than standard laxatives.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Children's Hospital Los Angeles
RECRUITINGLos Angeles, California, 90027, United States
Contact Email: •••••@•••••
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