Children's Hospital Los Angeles

This study tests whether butyrate enemas can help Hispanic children aged 7-21 with mild-to-moderate ulcerative colitis. Butyrate is a natural substance made by gut bacteria that may reduce inflammation. The goal is to see if it can lower disease activity scores and improve marker…

This study tests whether a 4-week online education program about continuous glucose monitors (CGMs) helps youth aged 8-21 with type 2 diabetes improve their blood sugar control compared to standard care. Participants will attend virtual sessions with a diabetes educator and use t…

This study tests a 10-week group intervention called Bridge the Gap, designed specifically for Black youth aged 12-17 who are having suicidal thoughts. The program adapts an existing suicide prevention model to be more culturally relevant. Researchers want to see if the group is …

This study tests two school-based sleep programs in 1,320 teens aged 12-18 with sleep problems. One program is a standard sleep health education, the other is a more intensive cognitive behavioral sleep intervention. Researchers will compare which program improves sleep quality m…

This study tests whether a sleep-focused therapy can improve depression in teenagers whose body clocks are out of sync with their wake-up time. Researchers will enroll 200 adolescents with depression and delayed sleep phase. The therapy aims to realign their internal circadian rh…

This study is testing whether a type of talk therapy called acceptance and commitment therapy (ACT) can help Black teenagers and young adults with sickle cell disease feel less stressed, anxious, and depressed. About 66 youth and their parents will join group therapy sessions and…

This pilot study tests whether Maralixibat, a drug that increases bile acids in the colon, can improve stool consistency in 20 children with cystic fibrosis who have chronic constipation. Participants will take the drug for two weeks alongside their usual laxatives. The goal is t…

This study tests whether using a virtual reality headset during interventional radiology procedures can reduce pain and anxiety in children aged 8 and older. About 500 participants will use the VR headset while undergoing their procedure, and researchers will compare their pain a…

This study tests whether shared medical appointments—where teens with type 2 diabetes meet their doctor in a group setting with educational activities—are a good way to deliver care. 160 teens aged 12-18 will either receive standard care or attend quarterly group clinics. Researc…

This study tests whether a Parent Navigator Program (PNP) helps Latino/x families of babies with congenital heart disease get connected to developmental follow-up services. Forty families will be randomly assigned to either receive support from a parent with lived experience or s…

This pilot study is testing a mobile health program designed to help adolescents and young adults (ages 15-20) with chronic health conditions remember to take their daily oral medications. Researchers want to see if the program is easy to use and if it improves medication adheren…

This study is creating a large research database of childhood cancer survivors treated at Children's Hospital Los Angeles. The goal is to track their long-term health, identify late effects from cancer therapy, and find ways to improve their quality of life. Up to 5,000 survivors…

This study tests whether short, social-media-style health education videos can help teens with chronic illnesses become more ready to manage their own healthcare. 44 teens will be randomly assigned to watch the videos or explore a standard health website. Researchers will measure…

This study looks at how different types of anesthesia change blood flow and oxygen use in the brains of children. Up to 1,000 kids having an MRI scan will be asked to join. The goal is to learn more, not to test a new treatment.

This study collects medical information and fluid from the front of the eye (aqueous humor) from up to 800 children with retinoblastoma, a rare eye cancer. Researchers aim to find biological markers in the fluid that can predict whether the eye can be saved with treatment. The st…

This study tests a computer program that gives doctors step-by-step advice on how to set breathing machines for children with acute respiratory distress syndrome (ARDS). The goal is to see if the tool can be used in multiple hospitals and if doctors follow its recommendations. Up…

This study tests whether a virtual education program called CGM Academy helps youth (ages 8-18) with type 1 diabetes improve their blood sugar control. Participants will receive an interactive workbook and four online group sessions with diabetes educators, while a comparison gro…

This study explores whether showing combat veterans with PTSD very brief, barely visible images of combat scenes can change their brain activity and reduce fear. Participants will view these images during an fMRI brain scan and rate their fear. The goal is to understand how the b…

This study explores whether showing youth with social anxiety disorder very brief, almost invisible images of judgmental faces can help rewire their brain's fear response. Eighty participants aged 16-22 will undergo brain scans while viewing these micro-exposures, and rate their …

This pilot study tests a simple idea: giving African American children ages 2-4 self-esteem themed books and advice during regular doctor visits. Researchers want to see if this helps parents reinforce positive self-concept and improves children's behavior and early reading skill…