Children's Hospital Los Angeles

This trial tests whether limiting eating to an early window (7 AM to 3 PM) or a late window (12 PM to 8 PM) helps adolescents with obesity lose weight and lower their body mass index. Participants aged 12 to 21 with obesity will follow one of these eating schedules for 24 weeks. …

This trial tests whether time-limited eating—consuming all food and drinks within an 8-hour period and fasting for the remaining 16 hours—can improve blood sugar control, insulin function, and body fat in adolescents with type 2 diabetes. Participants aged 12 to 21 will follow th…

This study tests whether adding a canine health-literacy module to an existing family lifestyle program helps overweight teens and their parents become more active. The program includes lessons on dog care, behavior, and exercise, along with activity trackers and surveys. Partici…

This study tested a drug called MEK162 in 105 children with low-grade gliomas or other tumors that have a specific overactive growth signal. The goal was to find the best dose, check for side effects, and see if the drug could shrink tumors. Children took the drug by mouth twice …

This study tested a computer program called REDvent that helps doctors set ventilators to match a child's natural breathing effort. The goal was to prevent the diaphragm from weakening while on a breathing machine. Researchers enrolled 248 children with lung disease who needed ve…

This study tested whether group-based telehealth visits could help teens with obesity manage their weight. 66 adolescents participated in 12 virtual sessions over 6 months, covering nutrition, physical activity, and mental health. Researchers compared their results to teens who a…

This study tested whether a health education program that focuses on reducing sugary drinks and juices, plus providing bottled water at home, can lower obesity risk in Hispanic mothers and their infants. Over 200 mother-infant pairs were randomly assigned to one of three groups: …

This study tested whether a mobile health program—including a Fitbit with movement reminders, coaching sessions, and a WhatsApp peer support group—could help 20 adolescents and young adults with acute lymphoblastic leukemia (ALL) reduce the time they spend sitting or lying down d…

This study tested whether a problem-solving skills program called Bright IDEAS helps parents of children undergoing stem cell transplants. Thirty-eight parents were randomly assigned to either the training or standard support. The goal was to see if the program is feasible and ac…

This study tests whether a smartphone app can help first-time parents in rural Guatemala track and encourage their baby's development. 220 families are taking part, with some using the app and others receiving standard care. Researchers will measure differences in language, motor…

This study tested whether an online parenting program called Incredible Years helps Filipino parents in California improve their parenting skills and reduce their children's behavior problems. About 360 families took part, with half receiving the program and half getting standard…

This study looked at whether shared medical appointments—where teens with type 2 diabetes meet together with their care team—are an acceptable way to deliver care. Researchers designed four group activities focused on nutrition, peer support, exercise, and stress management, and …