New hope for kids with brain tumors: targeted pill shows promise

NCT ID NCT02285439

Completed Disease control Sponsor: Children's Hospital Los Angeles Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a drug called MEK162 in 105 children with low-grade gliomas or other tumors that have a specific overactive growth signal. The goal was to find the best dose, check for side effects, and see if the drug could shrink tumors. Children took the drug by mouth twice daily for up to 2 years.

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Conditions

The condition(s) this trial relates to.

brain cancer low grade glioma neurofibromatosis type 1 soft tissue neoplasm Soft Tissue Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOW GRADE GLIOMAS MALIGNANT NEOPLASMS, BRAIN SOFT TISSUE NEOPLASMS

Contacts and locations

Locations

Children's Healthcare of Atlanta

Atlanta, Georgia, 30322, United States
Children's Hospital Los Angeles

Los Angeles, California, 90027, United States
Children's Hospital of Alabama

Birmingham, Alabama, 35233, United States
Children's Hospital of Colorado

Aurora, Colorado, 80045, United States
Children's Hospitals and Clinics of Minnesota-Minneapolis

Minneapolis, Minnesota, 55404, United States
Children's National Heath Systems

Washington D.C., District of Columbia, 20010, United States
Dana Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Johns Hopkins University

Baltimore, Maryland, 21287, United States
New York University

New York, New York, 10016, United States
Nicklaus Children's Hospital

Miami, Florida, 33155, United States
Oregon Health and Science University

Portland, Oregon, 97239, United States
Seattle Children's Hospital

Seattle, Washington, 98145, United States
Texas Children's Hospital

Houston, Texas, 77030, United States
University of Texas Southwestern Medical

Dallas, Texas, 75390, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States

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