New hope for chronic constipation: lubiprostone in Late-Stage trial
NCT ID NCT07277907
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 3 trial tests whether lubiprostone, a drug already used for other types of constipation, can safely increase bowel movements in people with slow transit constipation. About 346 adults will take either lubiprostone or a standard laxative (PEG) for 4 weeks. The main goal is to see if lubiprostone leads to more spontaneous bowel movements during the first week.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
lubiprostone
What this could lead to
If successful, this could provide a new, effective treatment option for people with slow transit constipation who have limited alternatives.
What could go wrong
This is a Phase 3 trial, but results may not confirm superiority over standard care (PEG). Side effects like nausea or diarrhea are possible.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Army Medical Center (Daping Hospital)
RECRUITINGYuzhong, Chongqing Municipality, 400042, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Bishan Hospital of Chongqing
NOT_YET_RECRUITINGBishan, Chongqing Municipality, 402760, China
Contact Phone: •••-•••-••••
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Chengdu Analrectal Hospital
NOT_YET_RECRUITINGChengdu, Sichuan, 610017, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Gansu Province Central Hospital
NOT_YET_RECRUITINGLanzhou, Gansu, 730079, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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General Hospital of the Eastern Theater Cammand of the PLA
NOT_YET_RECRUITINGNanjing, Jiangsu, 210002, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Renji Hospital, Shanghai Jiaotong University
NOT_YET_RECRUITINGPudong, Shanghai Municipality, 200127, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Shapingba Hospital, Chongqing University
NOT_YET_RECRUITINGShapingba, Chongqing Municipality, 400033, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Chenjiaqiao Hospital of ShaPingba District of Chongqing
NOT_YET_RECRUITINGShapingba, Chongqing Municipality, 401331, China
Contact Phone: •••-•••-••••
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The First Affiliated Hospital of Harbin Medical University
NOT_YET_RECRUITINGHarbin, Heilongjiang, 150007, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The General Hospital of Western Theater Command
NOT_YET_RECRUITINGChengdu, Sichuan, 610036, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Second People's Hospital of Yibin
NOT_YET_RECRUITINGYibin, Sichuan, 644000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Xijing Hospital
NOT_YET_RECRUITINGXi’an, Shanxi, 710032, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Zhejiang Provincial People's Hospital
NOT_YET_RECRUITINGHangzhou, Zhejiang, 310014, China
Contact Email: •••••@•••••
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Zhongnan Hospital of Wuhan University
NOT_YET_RECRUITINGWuhan, Hubei, 430062, China
Contact Email: •••••@•••••
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the People's Hospital of HeChuan Chongqing
NOT_YET_RECRUITINGHechuan, Chongqing Municipality, 401533, China
Contact Phone: •••-•••-•••• Email: •••••@•••••