New hope for chronic constipation: lubiprostone in Late-Stage trial

NCT ID NCT07277907

Recruiting now Symptom relief Sponsor: Third Military Medical University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 06, 2026 · Updated 2 times

Summary

This Phase 3 trial tests whether lubiprostone, a drug already used for other types of constipation, can safely increase bowel movements in people with slow transit constipation. About 346 adults will take either lubiprostone or a standard laxative (PEG) for 4 weeks. The main goal is to see if lubiprostone leads to more spontaneous bowel movements during the first week.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: lubiprostone
What this could lead to: If successful, this could provide a new, effective treatment option for people with slow transit constipation who have limited alternatives.
What could go wrong: This is a Phase 3 trial, but results may not confirm superiority over standard care (PEG). Side effects like nausea or diarrhea are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

constipation disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PHARMACOTHERAPY SLOW TRANSIT CONSTIPATION

Contacts and locations

Locations

Army Medical Center (Daping Hospital)
RECRUITING

Yuzhong, Chongqing Municipality, 400042, China
Bishan Hospital of Chongqing
NOT_YET_RECRUITING

Bishan, Chongqing Municipality, 402760, China
Chengdu Analrectal Hospital
RECRUITING

Chengdu, Sichuan, 610017, China
Gansu Province Central Hospital
NOT_YET_RECRUITING

Lanzhou, Gansu, 730079, China
General Hospital of the Eastern Theater Cammand of the PLA
NOT_YET_RECRUITING

Nanjing, Jiangsu, 210002, China
Mianyang 404 Hospital
NOT_YET_RECRUITING

Mianyang, Sichuan, 621000, China
Pengzhou People's Hospital
NOT_YET_RECRUITING

Pengzhou, Sichuan, 611930, China
Renji Hospital, Shanghai Jiaotong University
RECRUITING

Pudong, Shanghai Municipality, 200127, China
Shapingba District Traditional Chinese Medicine Hospital in Chongqing
NOT_YET_RECRUITING

Shapingba, Chongqing Municipality, 400000, China
Shapingba Hospital, Chongqing University
RECRUITING

Shapingba, Chongqing Municipality, 400033, China
The Chenjiaqiao Hospital of ShaPingba District of Chongqing
NOT_YET_RECRUITING

Shapingba, Chongqing Municipality, 401331, China
The First Affiliated Hospital of Harbin Medical University
RECRUITING

Harbin, Heilongjiang, 150007, China
The First Affiliated Hospital of Soochow University
RECRUITING

Suzhou, Jiangsu, 215006, China
The First Hospital of Hebei Medical University
NOT_YET_RECRUITING

Shijiazhuang, Hebei, 050000, China
The General Hospital of Western Theater Command
RECRUITING

Chengdu, Sichuan, 610036, China
The Second People's Hospital of Yibin
NOT_YET_RECRUITING

Yibin, Sichuan, 644000, China
Xijing Hospital
NOT_YET_RECRUITING

Xi’an, Shanxi, 710032, China
Zhejiang Provincial People's Hospital
NOT_YET_RECRUITING

Hangzhou, Zhejiang, 310014, China
Zhongnan Hospital of Wuhan University
NOT_YET_RECRUITING

Wuhan, Hubei, 430062, China
the People's Hospital of HeChuan Chongqing
NOT_YET_RECRUITING

Hechuan, Chongqing Municipality, 401533, China

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