Can Long-Acting injections stop stimulant psychosis from worsening?
NCT ID NCT03485417
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested two long-acting injectable medications, aripiprazole and paliperidone, in 165 people who use stimulants and have psychosis. The goal was to see if these drugs could better manage psychosis and prevent progression to chronic schizophrenia compared to standard treatment. Participants were randomly assigned to one of the two medications or to usual care, and their symptoms were tracked over time.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- aripiprazole and paliperidone (long-acting injectable forms)
- What this could lead to
- If successful, this could provide an evidence-based treatment strategy to better manage psychosis in people who use stimulants and reduce the risk of long-term dependence.
- What could go wrong
- This is a completed Phase 2/3 trial with 165 participants in Hong Kong, so results may not apply to other populations. The medications have side effects, and the study compares them to usual care, which may limit how broadly the findings can be used.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Queen Mary Hospital
Hong Kong, 000000, Hong Kong
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