The University Of Hong Kong

This study compares two mouthwashes used alongside standard gum disease treatment. One contains a higher dose of chlorhexidine (0.2%), while the other combines a lower dose of chlorhexidine (0.12%) with cetylpyridinium chloride. The goal is to see if the lower-dose combination wo…

This study tests a social work program called Project ReBond for people serving their first or second prison sentence in Hong Kong. The program includes workshops and counseling before release, plus support like job help and mentoring after release. Researchers will track 300 par…

This study is testing a new way to help women reduce their alcohol use. Participants will get brief counseling, daily check-ins via a phone app, and join a private social media support group. The goal is to see if this approach is practical and helpful for women who are at-risk d…

This study tests whether adding a hormone drug called Decapeptyl to standard IVF treatments can increase the number of live births. About 784 women under 43 with subfertility will receive either the drug or a placebo during egg retrieval and embryo transfer. The goal is to see if…

This study tests whether a combination of levonorgestrel (a hormone) and piroxicam (an anti-inflammatory drug) works better than the standard emergency contraceptive ulipristal acetate. About 980 women will take a single dose of either the combo or the standard pill, then be foll…

This study tests a 12-week program called HcELP_CMM that combines face-to-face counseling with WeChat-based support to help people with two or more heart-related conditions (like high blood pressure, diabetes, or heart disease) improve their lifestyle and health. Researchers will…

This study tests a program that combines brief advice, nicotine replacement therapy (like patches or gum), and text-message support to help smoking parents quit. The goal is to reduce children's exposure to secondhand smoke. About 1,200 smoking parents in Hong Kong who live with …

This pilot study tests whether high-dose vitamin D can help the body clear blood clots in the brain after a hemorrhagic stroke. Forty adults with a recent brain bleed will receive either vitamin D or standard care. Researchers will measure how fast the blood clot shrinks and chec…

This study looks at whether restarting blood thinners (DOACs) right after colonoscopy polyp removal is as safe as waiting two days. About 194 adults on DOACs who need a colonoscopy will be randomly assigned to restart their medication on the same day or two days later. The goal i…

This study tests a new method called PIPAC, which sprays chemotherapy directly into the abdomen as a fine mist. It is for people with stomach, pancreas, or colorectal cancer that has spread to the lining of the abdomen. The goal is to see if this approach can control the cancer a…

This study tests whether adding diquafosol eye drops to standard treatment helps people with moderate-to-severe vernal keratoconjunctivitis (a serious eye allergy). About 94 participants aged 6 and older will receive either diquafosol plus cyclosporine or cyclosporine alone. Rese…

This study follows 404 people who previously had either an AI-assisted or conventional colonoscopy. Researchers want to see if AI help lowers the risk of developing advanced colon polyps later. Participants will undergo a surveillance colonoscopy to check for new growths.

This study tests whether a scoring tool (TRICH score) can help doctors decide which patients who had a bleeding stroke should start three blood pressure medicines right away. The goal is to quickly lower blood pressure and reduce the risk of another stroke. About 140 adults in Ho…

This study tests a device called PTeye™ that uses near-infrared light to help surgeons see and protect tiny parathyroid glands during total thyroid removal. About 210 adults in Hong Kong will be randomly assigned to standard surgery or PTeye™-assisted surgery. The goal is to see …

This study tests a nurse-led program called TOP-S that helps people with metabolic syndrome make lasting lifestyle changes. 152 Chinese adults in Hong Kong will either get the full program or brief advice. Researchers will check if the program helps reverse metabolic syndrome and…

This study tests whether using a wearable fitness tracker, alone or with health coaching, helps adults aged 40+ with central obesity (belly fat) become more active and improve heart health markers. 133 participants will be split into three groups: one gets a Fitbit with coaching,…

This study tests whether the drug tranexamic acid can prevent brain bleed expansion in people with a type of stroke called intracerebral hemorrhage. The researchers are using new criteria to select patients most likely to benefit, based on bleed location and size. About 70 adults…

This study tests if a mobile health app can help people who had a bleeding stroke better control their blood pressure. About 140 participants will use the app to track their numbers and get health tips. The goal is to see if the app helps more people reach safe blood pressure lev…

This pilot study tests whether chat-based text messaging and an online education hub can reduce alcohol consumption and binge drinking in Hong Kong adolescents aged 12-18 who have drunk alcohol in the past year. One hundred participants will receive the digital intervention, whic…

This pilot study is testing whether combining stereotactic body radiation therapy (SBRT) with immunotherapy can shrink liver tumors that are too large or widespread to be surgically removed. The goal is to make these tumors operable, giving patients a chance at curative surgery. …

This study compares personalized oral hygiene advice from an AI app versus a human dentist in 148 adults with prediabetes and gum disease. The goal is to see if AI can improve gum health and blood sugar levels as well as a dentist. Participants will have their gums and blood suga…

This pilot study tests a spinal cord stimulator implanted at both the injury site and the lower back to help people with chronic spinal cord injury stand and walk. Five participants will go through three phases of stimulation over 9 months, combined with physiotherapy. The goal i…

This study is testing a non-invasive physical assessment to detect early signs of proprioceptive dysfunction in people with degenerative cervical myelopathy (DCM), a condition that affects balance and coordination. Researchers will enroll 100 Chinese adults aged 50 and older with…

This study is looking for markers in blood and saliva that can quickly tell if a person is having a stroke, and what kind. Researchers will collect samples from 650 adults with suspected stroke within 24 hours of symptoms. The goal is to develop a fast, accurate test to help emer…

This study tests whether a portable electronic stethoscope, combined with machine learning, can accurately detect valvular heart disease. About 125 people with and without the condition will use the device and also receive standard heart tests. Researchers will compare the device…

This study is testing whether artificial intelligence can accurately diagnose spinal deformities like scoliosis by analyzing photos of a person's bare back. Researchers will enroll 2,500 participants with various spinal conditions and compare the AI's assessment to standard X-ray…

This study aims to create a simple, fast test (like a pregnancy test) to detect poisonous substances from certain Chinese herbs (aconite) in urine. Current lab tests take too long, delaying treatment. Researchers will test the accuracy of this new device in 90 adults who may have…

This study compares AI-assisted upper endoscopy to standard high-definition endoscopy in 1,000 adults aged 40 and older who are scheduled for a routine upper endoscopy. The goal is to see if the AI tool helps doctors find more gastric neoplasms (abnormal growths) that might other…

This study tests whether a single injection of a GLP-1 drug (dulaglutide), given 1 to 14 days before planned non-cardiac surgery, can reduce heart muscle injury in 372 adults at risk. Participants are randomly assigned to receive the drug or standard care. The goal is to see if t…

This study tests whether the drug vericiguat can improve blood flow in the tiny vessels of the heart and reduce chest pain. About 94 adults aged 40-75 with stable chest pain but no major blockages will take the drug or a placebo. The main goal is to see if heart blood flow improv…

This study tests a new program called Mindful-Breath for people with chronic obstructive pulmonary disease (COPD). The program combines mindfulness, breathing exercises, and lifestyle coaching through group sessions and chat support. Researchers want to see if it is feasible and …

This study tests whether combining a brain stimulation technique called rTMS with a computer-based thinking exercise (CBM) can reduce negative thinking and depressive symptoms in people with mild-to-moderate depression. About 180 adults will receive either real or fake rTMS, and …

This study tests whether 8 weeks of mindfulness classes, taken together by people with Parkinson's and their family caregivers, can reduce negative emotions like stress, anxiety, and depression. About 200 Chinese patient-caregiver pairs will either take the classes or continue us…

This study tests whether acupressure can reduce coughing and related symptoms like shortness of breath and fatigue in lung cancer survivors. Eighty participants will either perform acupressure for 8 weeks or receive an educational booklet. Researchers will track changes in cough …

This study tests whether automated, personalized text messages can reduce mood and behavior symptoms in people with mild cognitive impairment (MCI). Researchers will enroll 160 adults aged 50 and older with early memory issues and mild behavioral symptoms. Participants receive da…

This study aims to identify and support hidden caregivers of older adults in Tai Po. Caregivers who are not currently using respite services will receive a combination of in-home respite, social worker follow-up, crisis management, and volunteer phone check-ins based on their nee…

This study tests whether a non-invasive brain stimulation technique called tDCS can improve mood and motivation in young adults (18-35) with mild depression. Participants will receive either real tDCS or a sham (placebo) treatment for 10 sessions over 2 weeks. Researchers will tr…

This trial tests whether a non-invasive radiofrequency device (Thermage FLX) plus eyelid gland expression can improve tear film stability better than gland expression alone in people with dry eye that hasn't responded to standard treatments. About 112 adults with moderate to seve…

This study tests whether cognitive stimulation therapy (CST) delivered by trained volunteers can improve thinking and quality of life for people with mild to moderate dementia. 520 participants in Hong Kong will either receive 7 weeks of volunteer-led CST sessions or continue wit…

This study compares a nurse-led mind-body program (including mindful breathing, stretching, and movement) to a befriending intervention for reducing loneliness in older adults living in long-term care. 120 residents aged 60 and older who can communicate in Cantonese/Chinese will …

This study tests a 20-week home exercise program called STEP@Home for people aged 60 and older who are at risk of losing strength and function after a hospital stay. The program includes balance, walking, and strength exercises tailored to each person. Researchers will measure ph…

This study tests a 16-week partner exercise program called BUDPA for people with mild dementia and their family caregivers. The program involves group workouts and at-home practice, aiming to improve thinking, mood, and the relationship between the pair. Researchers will track 23…

This study tests whether a non-invasive brain stimulation technique called rTMS, followed by intensive arm training, can reduce muscle stiffness (spasticity) in children aged 7–18 with hemiplegic cerebral palsy. Twenty participants will receive either real or sham rTMS over 10 da…

This study tests whether narrative therapy—a type of counseling that helps people reshape their personal stories—can reduce mental distress, depression, and anxiety in young people aged 12 to 24 in Hong Kong who are struggling with moderate mental health concerns. About 770 parti…

This study tests a program called COPE that combines mindfulness and cognitive behavioral therapy to help family caregivers of people with dementia. The goal is to reduce caregivers' stress, depression, and negative emotions like criticism or hostility toward their loved one. 56 …

This study tests whether a chatbot powered by large language models can help people with metabolic alcohol-related liver disease (MetALD) reduce their alcohol intake. About 50 adults in Hong Kong will use the chatbot for counseling. The main goal is to see if the approach is prac…

This study tests a chatbot called Digi-Coach to see if it can reduce physical and emotional distress in people receiving radiotherapy for head and neck cancer. About 138 adults will either use the chatbot alongside standard nursing care or receive usual care alone. The goal is to…

This study tests whether using ultrasound to show tongue movements on a screen can help children with speech sound disorders pronounce sounds better. Sixty children will be randomly assigned to get the therapy right away or wait a few weeks. The goal is to see if this visual feed…

This study tests whether a nurse-supported mobile app that teaches healthy sleep habits can reduce insomnia in people caring for a family member or friend with cancer. About 208 caregivers will either use the app for 6 weeks with weekly nurse check-ins or receive basic sleep tips…

This study tests whether a smartphone app, with or without personal coaching by phone, can improve sleep in children aged 6–12 with autism and insomnia. Parents use the app to learn behavioral sleep strategies. The trial will enroll 195 families and also measure effects on childr…

This study tests whether cognitive behavioral therapy for insomnia (CBT-I) can reduce impulsivity and risk-taking in young people aged 12-24 who have trouble sleeping. Researchers will measure changes in impulsive behavior and sleep quality. The goal is to see if improving sleep …

This study tests a group-based program for families of individuals with special health care needs. The program focuses on promoting psychological flexibility and value-guided living rather than changing distressing thoughts. Researchers will measure changes in stress, well-being,…

This study tests whether a 14-week elastic band exercise program can improve muscle mass, strength, and physical function in heart failure patients aged 50 and older who also have sarcopenia (age-related muscle loss). Researchers will measure changes in muscle, symptoms, and qual…

This study tests a 12-week program called ENACT that combines hearing exercises, memory training, and family support for people with mild cognitive impairment and hearing loss. Researchers want to see if it improves thinking, hearing, and quality of life compared to usual care. T…

This study tests three different doses of a long-acting numbing medicine (liposomal bupivacaine) injected into a nerve block in the thigh to control pain after total knee replacement. About 177 adults having robotic knee surgery will be randomly assigned to receive one of the dos…

This study tests an 18-week program where people with mild dementia and their family caregivers do sport stacking (a fast cup-stacking game) together at home. The goal is to see if it improves thinking skills, mood, and quality of life for both the person with dementia and their …

This study tests a 6-week WeChat-based program called SOCIAL_HF for elderly heart failure patients who feel socially frail. Participants join weekly video chats, do group tasks, and track daily health. The goal is to see if this online support improves social connections, self-ca…

This study tests an internet-based self-help program called eConquerFear-HK for Chinese cancer survivors who have mild to moderate fear of their cancer coming back. About 48 people who finished treatment for early-stage breast or colorectal cancer will try the program. The goal i…

This study tests whether a music therapy approach called therapeutic songwriting can improve mental health and social connections in university students who feel depressed, anxious, or stressed. Twenty participants will be randomly assigned to either four individual songwriting s…

This study tests whether a 'social story' — a short, step-by-step picture story — can help autistic preschool children feel less anxious and more cooperative during dental checkups. 106 children in Hong Kong will be split into two groups: one gets the dental story, the other gets…

This study follows 178 people who had a first episode of psychosis to see how early treatment choices and relapses affect their thinking, daily life, and mental health over 20 years. Participants attend one interview to assess symptoms, thinking skills, and functioning. The goal …

This study tests whether a virtual reality (VR) handwashing game helps secondary school students learn and remember proper handwashing skills better than watching a video or seeing a poster. About 500 students in Hong Kong will be split into three groups: two sessions of the VR g…

This study is looking at whether low-dose CT scans can find lung cancer early in people who have a parent, sibling, or child with lung cancer. The study includes 1,520 people aged 50 to 75, both smokers and non-smokers. Researchers want to see how many cases of lung cancer are fo…

This study tests whether motivational interviewing (a supportive conversation style) can help older adults who recently visited the ER and their family caregivers complete advance care plans. 300 pairs (older adult + caregiver) will either receive three counselling sessions or a …

This study checks how well a new version of a mental health interview (CIDI 5.0) can identify people who have had depression, anxiety, or PTSD at some point in their lives. Researchers in Hong Kong will interview 300 adults and compare the results with a detailed clinical assessm…

This study aims to create better criteria for deciding when to operate on Chinese patients with degenerative cervical myelopathy, a condition where the spinal cord is compressed. Researchers will test 100 surgical candidates using simple physical performance tests like hand grip …

This study tests a new tool called TRTRM that predicts which older cancer patients are at high risk for severe side effects from treatment. Researchers will use the tool to adjust drug doses and monitoring for patients aged 65 and older with solid tumors. The goal is to see if th…

This study aims to collect blood and saliva samples from 2000 adults who come to the emergency room with a suspected respiratory infection. Researchers will use these samples to better understand how the body responds to infections and to find new ways to diagnose and treat them.…

This study tests whether a specially designed game can help adults who have gone through major life stress feel more positive and resilient. Sixty participants will be split into three groups: one plays the game, one gets standard mental health education, and one waits. Researche…

This study tests whether a smartphone app (DigitHeart-2) can accurately predict heart structure and function from a simple ECG picture. About 478 adults who need an echocardiogram will have their ECG photo analyzed by the app, and the results will be compared to the standard ultr…

This study tests whether a training program for volunteers aged 50 and over can improve their knowledge about dementia, confidence in caregiving, and quality of life. Participants either receive 80-90 hours of BrainLive Coach training or just educational materials. The goal is to…

This study tests whether a nurse and allergist working together can safely and effectively remove incorrect penicillin allergy labels from patients' records. About 440 people with a penicillin allergy label will be evaluated using this team approach or the standard allergist-only…

This study tests whether using a life history calendar—a simple grid that helps people recall important life events—can improve the accuracy of mental health surveys. Researchers in Hong Kong will ask 2,500 adults about their mental health using either a standard interview or one…

This study looks at whether exercise, like walking and telehealth coaching, along with smoking cessation advice, can improve the lung function of smokers who already have early signs of lung trouble. Researchers will track 90 adults for a year to see if these steps help prevent c…

This study tests an artificial intelligence tool that automatically finds and maps skin blood vessels (perforators) from CT scans. These vessels are critical for a type of reconstructive surgery called fibula free flap, where bone and skin are moved to repair defects. The AI aims…

This study explores whether experiencing awe—through a simple online game featuring nature images—can increase people's willingness to engage in prosocial behaviors like getting vaccinated, wearing masks, and social distancing to prevent infectious diseases. Researchers will recr…

This study tests whether personalized exercise programs—like football, walking, or home-based workouts—help people over 60 stay healthy and independent. Nearly 2,000 participants will be assigned to different exercise types or a control group. Researchers will track physical abil…

This study looks at whether a program called Reach-and-Map helps older adults who are hard to reach stay healthy and independent. Researchers will measure quality of life, physical function, memory, loneliness, and depression in 5,500 participants aged 60 and older. The program a…