New study aims to find the best dose of long-lasting numbing medicine for knee surgery pain

NCT ID NCT06740214

Recruiting now Symptom relief Sponsor: The University of Hong Kong Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests three different doses of a long-acting numbing medicine (liposomal bupivacaine) injected into a nerve block in the thigh to control pain after total knee replacement. About 177 adults having robotic knee surgery will be randomly assigned to receive one of the doses or a placebo. The goal is to find which dose best reduces pain and the need for opioid painkillers in the first week after surgery.

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANALGESIC EFFECT DOSE RESPONSE RELATIONSHIP, DRUG LIPOSOMAL BUPIVACAINE PAIN, POSTOPERATIVE TOTAL KNEE ARTHROPLASTY

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

The University of Hong Kong
RECRUITING

Hong Kong, Hong Kong, Hong Kong

Contact Phone: •••-•••-•••• Email: •••••@•••••