Surgery showdown: which operation best treats stubborn constipation?
NCT ID NCT05352074
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This trial compares two types of colon surgery for people with severe slow-transit constipation that hasn't improved with other treatments. About 252 adults will be randomly assigned to have either a total colectomy (removing the whole colon) or a subtotal colectomy (removing most but not all of the colon). The goal is to see which surgery leads to better bowel function and quality of life.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
surgery (total colectomy with ileorectal anastomosis or subtotal colectomy with cecal-rectal anastomosis)
What this could lead to
If successful, this trial could identify which surgical approach offers better relief for people with severe, treatment-resistant constipation.
What could go wrong
This is a surgical trial with inherent risks like infection or bowel complications. Results may not apply to all patients, and surgery is a last resort after other treatments fail.
Disclaimer
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the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Army Medical Center (Daping Hospital)
Yuzhong, Chongqing Municipality, 400042, China
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Chengdu Analrectal Hospital
Chengdu, Sichuan, 610017, China
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General Hospital of the Eastern Theater Cammand of the PLA
Nanjing, Jiangsu, 210002, China
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No. 940 Hospital of Joint Logistics Support Force of Chinese People's Liberation Army
Lanzhou, Gansu, 730050, China
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Qingdao Municipal Hospital
Qingdao, Shandong, 266011, China
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Renji Hospital, Shanghai Jiaotong University
Pudong, Shanghai Municipality, 200127, China
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Renmin Hospital of Wuhan University
Wuhan, Hubei, 430060, China
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Shanghai Pudong New Area People's Hospital
Pudong, Shanghai Municipality, 201299, China
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The First Hospital of China Medical University
Shengyang, Liaoning, 110001, China
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The General Hospital of Western Theater Command
Chengdu, Sichuan, 610036, China
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The Second People's Hospital of Yibin
Yibin, Sichuan, 644000, China
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Xijing Hospital
Xi’an, Shanxi, 710032, China
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Zhejiang Provincial People's Hospital
Hangzhou, Zhejiang, 310014, China
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Zhongnan Hospital of Wuhan University
Wuhan, Hubei, 430062, China