Surgery showdown: which operation best treats stubborn constipation?

NCT ID NCT05352074

Ongoing Disease control Sponsor: Third Military Medical University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This trial compares two types of colon surgery for people with severe slow-transit constipation that hasn't improved with other treatments. About 252 adults will be randomly assigned to have either a total colectomy (removing the whole colon) or a subtotal colectomy (removing most but not all of the colon). The goal is to see which surgery leads to better bowel function and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: surgery (total colectomy with ileorectal anastomosis or subtotal colectomy with cecal-rectal anastomosis)
What this could lead to: If successful, this trial could identify which surgical approach offers better relief for people with severe, treatment-resistant constipation.
What could go wrong: This is a surgical trial with inherent risks like infection or bowel complications. Results may not apply to all patients, and surgery is a last resort after other treatments fail.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

constipation disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SLOW TRANSIT CONSTIPATION SURGERY

Contacts and locations

Locations

Army Medical Center (Daping Hospital)

Yuzhong, Chongqing Municipality, 400042, China
Chengdu Analrectal Hospital

Chengdu, Sichuan, 610017, China
General Hospital of the Eastern Theater Cammand of the PLA

Nanjing, Jiangsu, 210002, China
No. 940 Hospital of Joint Logistics Support Force of Chinese People's Liberation Army

Lanzhou, Gansu, 730050, China
Qingdao Municipal Hospital

Qingdao, Shandong, 266011, China
Renji Hospital, Shanghai Jiaotong University

Pudong, Shanghai Municipality, 200127, China
Renmin Hospital of Wuhan University

Wuhan, Hubei, 430060, China
Shanghai Pudong New Area People's Hospital

Pudong, Shanghai Municipality, 201299, China
The First Hospital of China Medical University

Shengyang, Liaoning, 110001, China
The General Hospital of Western Theater Command

Chengdu, Sichuan, 610036, China
The Second People's Hospital of Yibin

Yibin, Sichuan, 644000, China
Xijing Hospital

Xi’an, Shanxi, 710032, China
Zhejiang Provincial People's Hospital

Hangzhou, Zhejiang, 310014, China
Zhongnan Hospital of Wuhan University

Wuhan, Hubei, 430062, China

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