Can bowel flushes reshape the Gut's bacterial landscape?

NCT ID NCT05821309

Recruiting now Knowledge-focused Sponsor: Indiana University Source: ClinicalTrials.gov ↗

First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time

Summary

This study looks at whether a bowel flush regimen, using either MiraLAX or GoLytely, changes the types of bacteria in the gut of children with severe chronic constipation. Researchers will collect stool samples before and after a surgical procedure called an antegrade continence enema (ACE) placement, then compare the bacterial diversity at 1, 4, and 8 months. The goal is to see if these flushes cause a lasting shift in the microbiome, which could inform future treatment approaches.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PEG 3350 (MiraLAX) and PEG 3350 with electrolytes (GoLytely) bowel flush solutions
What this could lead to: If successful, this could reveal how bowel flush regimens shape gut bacteria, potentially guiding better constipation management in children.
What could go wrong: This is a small, early-stage study focused on microbiome changes, not clinical outcomes. Results may not apply broadly, and the microbiome may not change as expected.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

constipation disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CONSTIPATION

Contacts and locations

Locations

IU North Hospital
RECRUITING

Carmel, Indiana, 46032, United States
Riley Hospital for Children
RECRUITING

Indianapolis, Indiana, 46224, United States

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