Constipation disorder

This study tests whether transplanting healthy gut bacteria (fecal microbiota transplant, or FMT) combined with prebiotics can relieve chronic constipation. Nineteen adults with hard-to-treat constipation will receive the treatment via colonoscopy. The goal is to improve bowel mo…

This study tests whether an artificial intelligence (AI) tool can help doctors spot precancerous growths in the upper part of the colon during a colonoscopy. About 1,200 people with symptoms like belly pain, constipation, or black stools will take part. The goal is to see if usin…

This study will test whether a procedure called high-resolution anorectal manometry can help doctors figure out why some children have severe constipation that doesn't get better with standard treatments. The researchers will measure muscle and nerve function in the rectum and an…

This study tests whether teaching patients a gentle, circular belly massage (called effleurage) before abdominal surgery can help prevent constipation after the operation. About 42 adults having abdominal surgery will be split into two groups: one learns the massage technique and…

This study compares two laxatives, Senna and polyethylene glycol (PEG), to see which better reduces accidental bowel leakage in children with long-term constipation. About 80 children aged 4 to 18 will take one of the two medicines daily for 3 months, and neither the families nor…

This study tests whether Shouhui Tongbian Capsules, a traditional Chinese herbal medicine, can relieve constipation after surgery for benign anal or rectal conditions like hemorrhoids. 120 adults will be randomly assigned to take either the herbal capsules or a standard laxative …

This study tests whether a daily probiotic supplement called BLa36 can improve constipation in adults. Over 8 weeks, 105 participants will take either the probiotic or a placebo. Researchers will track stool consistency, gut health, and quality of life to see if the probiotic off…

This study tests whether a daily probiotic supplement can help relieve constipation in adults. Thirty participants will take either a probiotic or a placebo for 8 weeks. Researchers will track changes in stool consistency to see if the probiotics improve bowel function.

This study tests whether a probiotic called Akk09 can improve bowel movements and ease constipation symptoms in adults. About 70 participants will take either the probiotic or a placebo daily for 4 weeks. Researchers will track changes in stool consistency and overall gut health.

This study is testing a special probiotic supplement in 30 adults aged 50-65 who have ongoing bowel issues like constipation, irritable bowel syndrome, or stomach pain. The goal is to see if the probiotic can improve gut immunity, balance gut bacteria, and ease symptoms like bloa…

This study tests whether a daily fiber supplement (Materna® Opti-fiber) plus nutrition counseling can help pregnant women with constipation. About 31 women between 13 and 27 weeks of pregnancy will take the supplement for 4 weeks. Researchers will track changes in stool frequency…

This study tests whether electroacupuncture can help women with constipation after childbirth. About 60 women within 6 weeks of delivery will receive the treatment, and researchers will measure changes in stool consistency and quality of life. The goal is to find a safe, drug-fre…

This study tests a traditional Chinese medicine capsule, Shouhui Tongbian, to see if it can relieve constipation caused by opioid painkillers in cancer patients. About 270 adults with stable cancer and opioid-induced constipation will take either the capsule or a standard laxativ…

This study tests whether a daily mix of a probiotic (Bifidobacterium longum W11) and a prebiotic (Colopectin) can help children aged 2 to 6 with functional constipation stop taking macrogol laxatives without symptoms returning. One hundred children will receive either the supplem…

This study tests whether a 14-day course of the antibiotic rifaximin can reduce bothersome bloating in adults with irritable bowel syndrome, functional constipation, or similar gut disorders. About 78 participants will receive either rifaximin or a placebo, and researchers will m…

This study tests whether a game-based biofeedback therapy can improve quality of life and sleep in people with dyssynergic defecation, a condition where pelvic floor muscles don't relax properly during bowel movements. Thirty-six adults will either receive the game-based therapy …

This study compares two types of catheters used for bowel irrigation to help people with chronic constipation and/or fecal incontinence. About 66 adults will be randomly assigned to use either a new self-retaining catheter or a standard balloon catheter. Participants will be trai…

This study tests whether a functional food called Benemix® can safely improve bowel movements in adults with constipation. Eighty adults will take Benemix® daily for 15 days and track their bowel habits and any side effects. The goal is to see if this food product can ease consti…

This study tests two doses of linaclotide (72 mcg and 145 mcg) against a placebo in 90 adults with chronic constipation. Participants take the drug daily for 8 weeks and record their bowel movements and symptoms. The goal is to see if linaclotide improves bowel function and reduc…

This study tests a diet rich in soluble fiber and natural osmotic sugars (the SOLOS diet) to see if it improves constipation symptoms in adults with functional bowel disorders like IBS-C. Researchers will track stool frequency, form, and symptom severity in 180 participants. The …

This study tests whether a combined exercise and abdominal massage program can improve bowel function and daily well-being in children aged 5-18 with functional constipation. Researchers will compare the program to standard care by measuring symptoms, rectal size, and quality of …

This study tests whether drinking oat milk every day for 4 weeks can improve bowel movements in adults with constipation. About 100 participants will either drink oat milk or continue their normal diet. Researchers will track changes in gut bacteria, symptoms, and stool frequency…

This study will test whether standing on a whole-body vibration platform can improve constipation in women who have gone through menopause. Fifty women aged 50–60 will either receive standard bowel care advice or that advice plus vibration sessions. The goal is to see if the vibr…

This study will follow 100 people with severe obesity who are starting a GLP-1 drug (like Ozempic or Wegovy) to see if it causes new anal or rectal problems within the first 3 months. Participants will have a check-up before starting the drug and again after 3 months to look for …

This study looks at whether giving fish oil nutrition before colon surgery helps patients with constipation recover better. About 306 adults will either get fish oil before surgery or only after. Researchers will compare complication rates, recovery, and quality of life. The goal…

This study will create and test simple picture-based tools (pictograms) to help children aged 8 to 17 describe symptoms like constipation, bloating, and stomach pain. Many kids struggle to explain what they feel, which can lead to misdiagnosis. The goal is to see if these pictogr…

This study follows 80 adults who had a tube placed into their bowel (called a percutaneous endoscopic caecostomy, or PEC) to treat severe chronic constipation that didn't improve with standard treatments. Researchers will check long-term quality of life and how well the tube work…

This study will look at 150 infants and children aged 1 month to 4 years who are admitted to a hospital gastroenterology unit with a gastrointestinal disease. The goal is to find out how common electrolyte disturbances (like low sodium or potassium) are in these children. By meas…