Could a simple bowel rinse ease Parkinson's constipation and movement problems?
NCT ID NCT07716553
First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time
Summary
This study compares transanal irrigation (using a device to rinse the bowel) against standard care (diet, fluids, laxatives) for treating severe constipation in people with Parkinson's disease. Researchers will also check if the treatment affects gut bacteria and motor symptoms. Two hundred participants will be randomly assigned to one of the two approaches and followed for up to 24 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a transanal irrigation system (Qufora Flow device) for bowel management
- What this could lead to
- If effective, transanal irrigation could offer a non-drug option to manage severe constipation in Parkinson's disease, potentially improving quality of life and easing motor symptoms.
- What could go wrong
- This is a relatively small trial (200 people) and the device requires regular self-use, which may not suit everyone. Benefits for motor symptoms or microbiome changes are exploratory and uncertain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for CONSTIPATION are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
University Hospital Ferrara
Ferrara, Ferrara, 44100, Italy
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Blood-flow cuffs may mimic exercise to ease Parkinson's symptoms
- Yogurt as medicine? Butyrate-Rich formula tested for Cancer-Related constipation
- Shake or sync: two therapies put to the test for Parkinson's mobility
- Wearable sensors aim to catch neurodegenerative decline in real time
- Can deep brain stimulation rewire faulty movement circuits? a surgery-time study aims to find out.
- The eyes as a window to the brain: can a simple scan monitor MS, Alzheimer's, and Parkinson's?