New drug aims to ease chronic constipation in large trial

NCT ID NCT07382167

Recruiting now Symptom relief Sponsor: Ardelyx Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests three doses of tenapanor (5, 25, or 50 mg twice daily) against a placebo in 692 adults with chronic idiopathic constipation. Over 26 weeks, researchers will check if the drug increases complete spontaneous bowel movements. The goal is to find a safe, effective option for people with this condition.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

tenapanor

What this could lead to

If it works, this could provide a new daily medication option for people with chronic constipation who haven't found relief.

What could go wrong

This is a Phase 3 trial, but the drug may not work better than placebo, or side effects could limit its use. Results are not yet known.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

constipation disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC IDIOPATHIC CONSTIPATION (CIC)

Contacts and locations

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310 Clinical Research
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Inglewood, California, 90301, United States

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3A Research
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El Paso, Texas, 79925, United States

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Accellacare of Bristol
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Bristol, Tennessee, 37620, United States

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Accellacare of Cary
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Cary, North Carolina, 27518, United States

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Accellacare of Knoxville
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Knoxville, Tennessee, 37938, United States

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Accellacare of Piedmont HealthCare
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Statesville, North Carolina, 28625, United States

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Accellacare of Raleigh
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Raleigh, North Carolina, 27609, United States

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Accellacare of Rocky Mount
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Rocky Mount, North Carolina, 27804, United States

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Accellacare of Salisbury
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Salisbury, North Carolina, 28144, United States

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Accellacare of Winston-Salem, Triad Neurological Associates
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Winston-Salem, North Carolina, 27103, United States

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Acclaim Clinical Research
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San Diego, California, 92120, United States

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Advanced Research Institute - Denver
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Denver, Colorado, 80218, United States

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Advanced Research Institute - Ogden
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Ogden, Utah, 84405, United States

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Advanced Research Institute - Portland
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Tigard, Oregon, 97223, United States

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Advanced Research Institute - Reno
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Reno, Nevada, 89511, United States

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Advanced Research Institute - Sandy
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Sandy City, Utah, 84092, United States

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Agile Clinical Research Trials, LLC
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Atlanta, Georgia, 30328, United States

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Albuquerque Clinical Trials (ACT)
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Albuquerque, New Mexico, 87102, United States

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Allied Digestive Health - Jersey Shore Gastroenterology - Point Commons
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Somers Point, New Jersey, 08244, United States

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Allied Health Clinical Research Organization, LLC (AHCRO) - Jackson
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Jackson, New Jersey, 08724, United States

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Arizona Liver Health - Chandler
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Chandler, Arizona, 85225, United States

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Arkansas Gastroenterology - North Little Rock
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North Little Rock, Arkansas, 72117, United States

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Bay State Clinical Trials
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Watertown, Massachusetts, 02472, United States

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Centricity Research Columbus Ohio Multispecialty
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Columbus, Ohio, 43213, United States

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Charlottesville Medical Research Center, LLC
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Charlottesville, Virginia, 22911, United States

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Cleveland Clinic
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Cleveland, Ohio, 44195, United States

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Clinical Investigation Specialists, Inc
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Gurnee, Illinois, 60031, United States

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Clinical Neuroscience Solutions, Inc - Memphis
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Memphis, Tennessee, 38119, United States

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Clinical Research Center of Florida
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Pompano Beach, Florida, 33060, United States

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Clinical Research Institute of Arizona, LLC
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Sun City West, Arizona, 85375, United States

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Clinical Trials Research
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Lincoln, California, 95648, United States

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Coastal Carolina Research Center
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North Charleston, South Carolina, 29405, United States

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Coastal Research Institute, LLC
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Fayetteville, North Carolina, 28304, United States

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Del Sol Research Management, LLC
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Tucson, Arizona, 85715, United States

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DelRicht Clinical Research - Atlanta
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Atlanta, Georgia, 30329, United States

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DelRicht Clinical Research - Charleston
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Charleston, South Carolina, 29407, United States

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DelRicht Clinical Research - Covington
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Mandeville, Louisiana, 70471, United States

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DelRicht Clinical Research - Gulfport
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Gulfport, Mississippi, 39503, United States

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DelRicht Clinical Research - Indianapolis
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Indianapolis, Indiana, 46202, United States

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DelRicht Clinical Research - Louisville
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Louisville, Kentucky, 40205, United States

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DelRicht Clinical Research - McKinney
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Prosper, Texas, 75078, United States

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DelRicht Clinical Research - Nashville
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Hendersonville, Tennessee, 37075, United States

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DelRicht Clinical Research - New Orleans
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New Orleans, Louisiana, 70115, United States

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DelRicht Clinical Research - Overland Park
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Overland Park, Kansas, 66209, United States

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DelRicht Clinical Research - Prairieville
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Prairieville, Louisiana, 70769, United States

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DelRicht Clinical Research - Springfield
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Springfield, Missouri, 65807, United States

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DelRicht Clinical Research - Town and Country
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Town and Country, Missouri, 63017, United States

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DelRicht Clinical Research - Tulsa
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Tulsa, Oklahoma, 74133, United States

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DelRicht Clinical Research - Vienn
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Vienna, Virginia, 22182, United States

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Delricht Clinical Research - Badmus
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Charlotte, North Carolina, 28210, United States

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Delta Research Partners of West Monroe, LLC
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West Monroe, Louisiana, 71291, United States

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Digestive Disease Specialists
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Las Vegas, Nevada, 89128, United States

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Drug Trials America
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Hartsdale, New York, 10530, United States

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EPIC Medical Research
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DeSoto, Texas, 75115, United States

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Elite Clinical Studies
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Phoenix, Arizona, 85018, United States

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Elite Clinical Trials-Idaho
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Blackfoot, Idaho, 83221, United States

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Elixia SISU BHR - Sprinfield
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Springfield, Massachusetts, 01103, United States

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Erick H. Alayo Medical Corporation
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Chula Vista, California, 91910, United States

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Evanston Premier Healthcare Research LLC
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Skokie, Illinois, 60077, United States

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Excel Clinical Research
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Las Vegas, Nevada, 89109, United States

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G & L Research, LLC
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Foley, Alabama, 36535, United States

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GI Alliance - Glenview, IL
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Glenview, Illinois, 60026, United States

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GW Research Inc.
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Chula Vista, California, 91010, United States

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Gastrointestinal Associates LLP
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Columbia Falls, Montana, 65201, United States

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Gastrointestinal Specialists of Georgia PC
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Marietta, Georgia, 30060, United States

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Great Lakes Gastroenterology Research
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Mentor, Ohio, 44060, United States

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Harmony Clinical Research - Orlando
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Orange City, Florida, 32763, United States

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Harmony Clinical Research, Inc - North Miami Beach
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Miami Beach, Florida, 33162, United States

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Health Research of Hampton Roads, Inc. - Newport News
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Newport News, Virginia, 23606, United States

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Hometown Urgent Care and Research - Huber Heights
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Huber Heights, Ohio, 45424, United States

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Hope Clinical Research - Canoga Park
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Canoga Park, California, 91303, United States

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IMIC, Inc
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Miami, Florida, 33176, United States

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Jubilee Clinical Research, Inc.
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Las Vegas, Nevada, 89106, United States

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Kansas City Research Institute
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Kansas City, Missouri, 64131, United States

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Lillestol Research, LLC
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Fargo, North Dakota, 58104, United States

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LinQ Research, LLC
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Pearland, Texas, 77584, United States

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Lucas Research - Diabetes & Endocrinology Consultants, PC
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Morehead City, North Carolina, 28557, United States

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NY Scientific
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Brooklyn, New York, 11235, United States

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New Phase Research & Development - Knoxville
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Knoxville, Tennessee, 37909, United States

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North Georgia Clinical Research
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Woodstock, Georgia, 30189, United States

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North Hills Medical Research Inc. (North Hills Family Medicine)
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North Richland Hills, Texas, 76180, United States

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Om Research LLC
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Lancaster, California, 93534, United States

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Paragon Rx Clinical, Inc. - Santa Ana
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Santa Ana, California, 92703, United States

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Peters Medical Research
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High Point, North Carolina, 27260, United States

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Proactive Clinical Research
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Fort Lauderdale, Florida, 33308, United States

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Quality Medical Research, PLLC
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Nashville, Tennessee, 37211, United States

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Remington Davis, Inc.
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Columbus, Ohio, 43215, United States

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Rocky Mountain Gastroenterology (RMG) - Littleton
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Lakewood, Colorado, 80228, United States

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San Jose Gastroenterology
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San Jose, California, 95128, United States

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Sensible Healthcare, LLC
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Ocoee, Florida, 34761, United States

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Southwest Gastroenterology
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Oak Lawn, Illinois, 60453, United States

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St. Charles Clinical Research
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St Louis, Missouri, 63141, United States

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Sun Research Institute
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San Antonio, Texas, 78215, United States

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Suncoast Clinical Research, Inc. - New Port Richey
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New Port Richey, Florida, 34652, United States

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Suncoast Clinical Research, Inc. - Palm Harbor
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Palm Harbor, Florida, 34684, United States

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Tandem Clinical Research
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Marrero, Louisiana, 70072, United States

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Tandem Clinical Research GI - Houma
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Houma, Louisiana, 70363, United States

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Tekton Research - Longmont, CO
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Longmont, Colorado, 80501, United States

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Tekton Research - Wichita, KS
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Wichita, Kansas, 67218, United States

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Tekton Research - Yukon, OK
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Yukon, Oklahoma, 73099, United States

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Texas Gastro Consultants
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Tomball, Texas, 77375, United States

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The Center for Clinical Trials
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Saraland, Alabama, 36571, United States

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Treasure Valley Medical Research
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Boise, Idaho, 83706, United States

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University of Michigan Health System
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Ann Arbor, Michigan, 48109, United States

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Valencia Medical and Research Center
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Miami, Florida, 33174, United States

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Wasatch Clinical Research, LLC
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Salt Lake City, Utah, 84107, United States

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Waterway Research
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Miami, Florida, 33155, United States

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Woodholme Gastroenterology
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Glen Burnie, Maryland, 21061, United States

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Zenos Clinical Research
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Dallas, Texas, 75230, United States

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