New hope for kids on painkillers: constipation relief drug under study

NCT ID NCT05588323

Recruiting now Symptom relief Sponsor: Shionogi Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 29, 2026 · Updated 2 times

Summary

This study is testing a medicine called naldemedine to help children who get constipated from taking opioids (strong painkillers). About 24 children with cancer or other pain conditions will receive a single dose of the drug. Researchers will measure how the drug moves through the body and check for side effects.

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Conditions

The condition(s) this trial relates to.

opioid-induced constipation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OPIOID-INDUCED CONSTIPATION (OIC)

Contacts and locations

Locations

CHU Saint-Pierre Clinical Trials Unit
COMPLETED

Brussels, Belgium
Chu de Caen
COMPLETED

Caen, 14033, France
Citta della Salute e della Scienza di Torino
COMPLETED

Torino, Italy
Hôpital Armand Trousseau Service Hématologie et Oncologie Pédiatrique
COMPLETED

Paris, France
Hôpital Béclère Service de Pédiatrie Centre de Référence des Maladies Héréditaires du Métabolisme Hépatique (CRMHMH)
COMPLETED

Clamart, France
Hôpital Jeanne de Flandre Antenne du CIC pédiatrique - Niveau 0 CHU de Lille
COMPLETED

Lille, France
Instituto Nazionale dei Tumori
COMPLETED

Milan, Italy
Maternal and Child Health Institute IRCCS Burlo Garofolo, Pain and pediatric palliative care service
COMPLETED

Trieste, Italy
National Center for Child Health and Development
NOT_YET_RECRUITING

Tokyo, Japan
PHI University Clinic for Children's , Surgery
RECRUITING

Skopje, North Macedonia
Universitair Ziekenhuis Brussel (UZBrussel) - Department of Anesthesiology and Perioperative Medicine
COMPLETED

Brussels, Belgium
University Center Mother Theresa , Hospital - Onco-hematology department
NOT_YET_RECRUITING

Tirana, Albania
University Clinic for Childrens Diseases , Department of Oncology, Hematology and , Malignant Hemopathy
RECRUITING

Skopje, North Macedonia
University Clinical Hospital , Mostar
RECRUITING

Mostar, Bosnia and Herzegovina
University Hospitals Leuven Pediatrisch hemato-oncology
COMPLETED

Leuven, Belgium
Yeolyan Hematology. , and Oncology Center -
RECRUITING

Yerevan, Armenia

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