Mayo clinic tests Brain-Bowel retraining for constipation relief
NCT ID NCT07225803
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study at Mayo Clinic tests whether biofeedback therapy and inspiratory muscle training can help people with dyssynergic defecation—a condition where pelvic floor muscles don't relax properly during bowel movements. Two hundred adults aged 18 to 80 with chronic constipation will learn to retrain their muscles using computer monitors and breathing exercises. The goal is to improve bowel emptying and reduce symptoms without medication.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
biofeedback therapy and inspiratory muscle training
What this could lead to
If successful, this could lead to better, non-drug treatments for chronic constipation caused by poor coordination of pelvic floor muscles.
What could go wrong
This is an early-stage behavioral study with no control group, so results may not prove the treatments work better than standard care. Success depends on patient effort and adherence.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Mayo Clinic
RECRUITINGRochester, Minnesota, 55905, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••