Needle-Free drug delivery tested for bowel issues

NCT ID NCT04027972

Completed Knowledge-focused Sponsor: James J. Peters Veterans Affairs Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This early-phase trial in 13 healthy volunteers measures how two drugs, neostigmine and glycopyrrolate, enter the bloodstream when given through a skin patch using a mild electric current (iontophoresis) compared to an IV. The goal is to see if this needle-free method could one day help people with spinal cord injuries manage bowel problems. The study only looks at drug levels and short-term side effects, not whether the drugs actually improve bowel function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: neostigmine and glycopyrrolate
What this could lead to: If successful, this could point toward a needle-free way to deliver these drugs for bowel issues in spinal cord injury patients.
What could go wrong: This is a very early, small study in healthy people, not patients. It only measures drug levels, not whether the treatment works for bowel problems.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for CONSTIPATION are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

constipation disorder Encopresis Fecal Incontinence neurogenic bowel spinal cord injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CONSTIPATION FECAL INCONTINENCE NEUROGENIC BOWEL SPINAL CORD INJURIES

Contacts and locations

Locations

James J Peters VA Medical Center

The Bronx, New York, 10468, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.