Needle-Free drug delivery tested for bowel issues
NCT ID NCT04027972
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This early-phase trial in 13 healthy volunteers measures how two drugs, neostigmine and glycopyrrolate, enter the bloodstream when given through a skin patch using a mild electric current (iontophoresis) compared to an IV. The goal is to see if this needle-free method could one day help people with spinal cord injuries manage bowel problems. The study only looks at drug levels and short-term side effects, not whether the drugs actually improve bowel function.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
neostigmine and glycopyrrolate
What this could lead to
If successful, this could point toward a needle-free way to deliver these drugs for bowel issues in spinal cord injury patients.
What could go wrong
This is a very early, small study in healthy people, not patients. It only measures drug levels, not whether the treatment works for bowel problems.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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James J Peters VA Medical Center
The Bronx, New York, 10468, United States