CONSTIPATION

This study tests whether an artificial intelligence (AI) tool can help doctors spot precancerous growths in the upper part of the colon during a colonoscopy. About 1,200 people with symptoms like belly pain, constipation, or black stools will take part. The goal is to see if usin…

This study compares transanal irrigation (using a device to rinse the bowel) against standard care (diet, fluids, laxatives) for treating severe constipation in people with Parkinson's disease. Researchers will also check if the treatment affects gut bacteria and motor symptoms. …

This study tests whether a probiotic called Akk09 can improve bowel movements and ease constipation symptoms in adults. About 70 participants will take either the probiotic or a placebo daily for 4 weeks. Researchers will track changes in stool consistency and overall gut health.

This phase II trial investigates whether a specially formulated yogurt rich in butyrate—a short-chain fatty acid—can relieve constipation in people with gastrointestinal cancer. Constipation is a common and distressing side effect of cancer and its treatments, and current medicat…

This study tests whether Shouhui Tongbian Capsules, a traditional Chinese herbal medicine, can relieve constipation after surgery for benign anal or rectal conditions like hemorrhoids. 120 adults will be randomly assigned to take either the herbal capsules or a standard laxative …

This study tests whether a dietary supplement can improve constipation and related symptoms like gas and bloating. About 550 adults with constipation will take either the active supplement or a placebo for 4 weeks. Researchers will measure changes in constipation severity and dig…

This study tests whether a daily probiotic supplement can help relieve constipation in adults. Thirty participants will take either a probiotic or a placebo for 8 weeks. Researchers will track changes in stool consistency to see if the probiotics improve bowel function.

This study tests whether a 14-day course of the antibiotic rifaximin can reduce bothersome bloating in adults with irritable bowel syndrome, functional constipation, or similar gut disorders. About 78 participants will receive either rifaximin or a placebo, and researchers will m…

This study tests whether a functional food called Benemix® can safely improve bowel movements in adults with constipation. Eighty adults will take Benemix® daily for 15 days and track their bowel habits and any side effects. The goal is to see if this food product can ease consti…

This study tests a diet rich in soluble fiber and natural osmotic sugars (the SOLOS diet) to see if it improves constipation symptoms in adults with functional bowel disorders like IBS-C. Researchers will track stool frequency, form, and symptom severity in 180 participants. The …

This study tests whether drinking oat milk every day for 4 weeks can improve bowel movements in adults with constipation. About 100 participants will either drink oat milk or continue their normal diet. Researchers will track changes in gut bacteria, symptoms, and stool frequency…

This study will test whether standing on a whole-body vibration platform can improve constipation in women who have gone through menopause. Fifty women aged 50–60 will either receive standard bowel care advice or that advice plus vibration sessions. The goal is to see if the vibr…

This study will follow 100 people with severe obesity who are starting a GLP-1 drug (like Ozempic or Wegovy) to see if it causes new anal or rectal problems within the first 3 months. Participants will have a check-up before starting the drug and again after 3 months to look for …

This study looks at whether giving fish oil nutrition before colon surgery helps patients with constipation recover better. About 306 adults will either get fish oil before surgery or only after. Researchers will compare complication rates, recovery, and quality of life. The goal…

This study follows 80 adults who had a tube placed into their bowel (called a percutaneous endoscopic caecostomy, or PEC) to treat severe chronic constipation that didn't improve with standard treatments. Researchers will check long-term quality of life and how well the tube work…