New hope for immunocompromised skin cancer patients: amivantamab combo tested

NCT ID NCT07042295

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 14, 2026 · Updated 12 times

Summary

This phase II trial tests whether a combination of amivantamab and hyaluronidase works as well as cetuximab for treating skin squamous cell carcinoma that has come back or spread. The study enrolls 86 immunocompromised participants, including organ transplant recipients. The goal is to compare safety and effectiveness, with a focus on controlling the cancer rather than curing it.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: amivantamab and hyaluronidase
What this could lead to: If it works, this could offer a new treatment option for immunocompromised patients with advanced skin cancer that has returned or spread.
What could go wrong: This is a small, early-phase trial that is currently suspended. The treatment may cause serious side effects like skin rash or organ rejection in transplant patients, and it may not work better than the existing drug cetuximab.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

metastatic squamous cell carcinoma skin squamous cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALLY RECURRENT SKIN SQUAMOUS CELL CARCINOMA METASTATIC SKIN SQUAMOUS CELL CARCINOMA

Contacts and locations

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Locations

Banner MD Anderson Cancer Center
RECRUITING

Gilbert, Arizona, 85234, United States
Carle BroMenn Medical Center
RECRUITING

Normal, Illinois, 61761, United States

Contact Email: •••••@•••••
Carle Cancer Center
RECRUITING

Urbana, Illinois, 61801, United States

Contact Email: •••••@•••••
Carle Cancer Institute Normal
RECRUITING

Normal, Illinois, 61761, United States

Contact Email: •••••@•••••
Carle Physician Group-Effingham
RECRUITING

Effingham, Illinois, 62401, United States

Contact Email: •••••@•••••
Carle Physician Group-Mattoon/Charleston
RECRUITING

Mattoon, Illinois, 61938, United States

Contact Email: •••••@•••••
Carle at The Riverfront
RECRUITING

Danville, Illinois, 61832, United States

Contact Email: •••••@•••••
Case Western Reserve University
RECRUITING

Cleveland, Ohio, 44106, United States

Contact Email: •••••@•••••
Drexel Town Square Health Center
RECRUITING

Oak Creek, Wisconsin, 53154, United States
Froedtert Menomonee Falls Hospital
RECRUITING

Menomonee Falls, Wisconsin, 53051, United States
Froedtert West Bend Hospital/Kraemer Cancer Center
RECRUITING

West Bend, Wisconsin, 53095, United States
Froedtert and MCW Moorland Reserve Health Center
RECRUITING

New Berlin, Wisconsin, 53151, United States
Henry Ford Hospital
RECRUITING

Detroit, Michigan, 48202, United States

Contact Email: •••••@•••••
Huntsman Cancer Institute/University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States

Contact Email: •••••@•••••
Ingalls Memorial Hospital
RECRUITING

Harvey, Illinois, 60426, United States

Contact Email: •••••@•••••
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Memorial Sloan Kettering Basking Ridge
RECRUITING

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Commack
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau
RECRUITING

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester
RECRUITING

Harrison, New York, 10604, United States
Penn State Milton S Hershey Medical Center
RECRUITING

Hershey, Pennsylvania, 17033-0850, United States
Smilow Cancer Hospital Care Center - Waterford
RECRUITING

Waterford, Connecticut, 06385, United States

Contact Email: •••••@•••••
Smilow Cancer Hospital Care Center-Trumbull
RECRUITING

Trumbull, Connecticut, 06611, United States

Contact Email: •••••@•••••
UC Comprehensive Cancer Center at Silver Cross
RECRUITING

New Lenox, Illinois, 60451, United States

Contact Email: •••••@•••••
UC San Diego Moores Cancer Center
RECRUITING

La Jolla, California, 92093, United States

Contact Email: •••••@•••••
UCHealth University of Colorado Hospital
RECRUITING

Aurora, Colorado, 80045, United States
UChicago Medicine Northwest Indiana
RECRUITING

Crown Point, Indiana, 46307, United States

Contact Email: •••••@•••••
UH Seidman Cancer Center at UH Avon Health Center
RECRUITING

Avon, Ohio, 44011, United States
UHHS-Chagrin Highlands Medical Center
RECRUITING

Beachwood, Ohio, 44122, United States

Contact Email: •••••@•••••
UPMC Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
USC / Norris Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90033, United States
UT MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
University of Alabama at Birmingham Cancer Center
RECRUITING

Birmingham, Alabama, 35233, United States
University of Chicago Comprehensive Cancer Center
RECRUITING

Chicago, Illinois, 60637, United States

Contact Email: •••••@•••••
University of Chicago Medicine-Orland Park
RECRUITING

Orland Park, Illinois, 60462, United States

Contact Email: •••••@•••••
University of Cincinnati Cancer Center-UC Medical Center
RECRUITING

Cincinnati, Ohio, 45219, United States

Contact Email: •••••@•••••
University of Cincinnati Cancer Center-West Chester
RECRUITING

West Chester, Ohio, 45069, United States

Contact Email: •••••@•••••
University of Michigan Rogel Cancer Center
RECRUITING

Ann Arbor, Michigan, 48109, United States

Contact Email: •••••@•••••
Yale University
RECRUITING

New Haven, Connecticut, 06520, United States

Contact Email: •••••@•••••

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