Calorie cutting may reverse a key step toward diabetes

NCT ID NCT02193295

Recruiting now Disease control Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study investigates whether reducing calories to lower fat in the liver and muscles can improve how the body responds to insulin. Researchers will measure changes in insulin sensitivity and fat levels in 250 healthy but insulin-resistant adults with a family history of type 2 diabetes. Participants follow a calorie-restricted diet with weekly check-ins, and results are compared before and after the intervention.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: caloric restriction
What this could lead to: If successful, this approach could point toward a non-drug way to reverse insulin resistance and reduce the risk of type 2 diabetes and fatty liver disease.
What could go wrong: This is a small, early-stage study focused on biological markers, not long-term health outcomes. Results may not apply to everyone, and maintaining weight loss can be challenging.

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Conditions

The condition(s) this trial relates to.

Insulin Resistance metabolic dysfunction-associated steatotic liver disease pinta disease Weight Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INSULIN RESISTANCE NAFLD

Contacts and locations

Locations

Magnetic Resonance Research Center (MRRC)
ENROLLING_BY_INVITATION

New Haven, Connecticut, 06511, United States
Yale Center for Clinical Investigation HRU
RECRUITING

New Haven, Connecticut, 06520, United States

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