Calorie cutting may reverse a key step toward diabetes
NCT ID NCT02193295
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study investigates whether reducing calories to lower fat in the liver and muscles can improve how the body responds to insulin. Researchers will measure changes in insulin sensitivity and fat levels in 250 healthy but insulin-resistant adults with a family history of type 2 diabetes. Participants follow a calorie-restricted diet with weekly check-ins, and results are compared before and after the intervention.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
caloric restriction
What this could lead to
If successful, this approach could point toward a non-drug way to reverse insulin resistance and reduce the risk of type 2 diabetes and fatty liver disease.
What could go wrong
This is a small, early-stage study focused on biological markers, not long-term health outcomes. Results may not apply to everyone, and maintaining weight loss can be challenging.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Magnetic Resonance Research Center (MRRC)
ENROLLING_BY_INVITATIONNew Haven, Connecticut, 06511, United States
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Yale Center for Clinical Investigation HRU
RECRUITINGNew Haven, Connecticut, 06520, United States
Contact Phone: •••-•••-••••
Contact