New pill for eczema enters first human tests

NCT ID NCT07558668

Recruiting now Symptom relief Sponsor: Sitryx Therapeutics Ltd Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage study tests a new oral drug called SYX-5219 in healthy volunteers and people with moderate to severe atopic dermatitis (eczema). The main goal is to check safety and how the drug moves through the body. About 149 participants will take single or multiple doses over 42 days. It is too early to know if the drug works.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: SYX-5219 oral capsule
What this could lead to: If successful, this could lead to a new oral treatment option for moderate to severe atopic dermatitis, potentially easing symptoms like itching and inflammation.
What could go wrong: This is a very early Phase 1 trial focused on safety, not yet on effectiveness. The drug may fail to show benefit or cause side effects. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atopic eczema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MODERATE-TO-SEVERE ATOPIC DERMATITIS

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••
Contact

Email: •••••@•••••

Locations

Sitryx Clinical Site
RECRUITING

Arkansas City, Arkansas, 72117, United States
Sitryx Clinical Site
RECRUITING

Fremont, California, 94538, United States
Sitryx Clinical Site
RECRUITING

Plainfield, Indiana, 46168, United States
Sitryx Clinical Site
RECRUITING

Boardman, Ohio, 44512, United States
Sitryx Clinical Site
RECRUITING

Philadelphia, Pennsylvania, 19103, United States
Sitryx Clinical Site
RECRUITING

Bountiful, Utah, 84010, United States
Sitryx Clinical Site
RECRUITING

Sofia, 1404, Bulgaria
Sitryx Clinical Site
NOT_YET_RECRUITING

Herlev, Herlev, 2730, Denmark
Sitryx Clinical Site
RECRUITING

Berlin, 10117, Germany
Sitryx Clinical Site
RECRUITING

Frankfurt, 60596, Germany
Sitryx Clinical Site
ACTIVE_NOT_RECRUITING

Freiburg im Breisgau, 79106, Germany
Sitryx Clinical Site
RECRUITING

Dublin, D08 NHY1, Ireland
Sitryx Clinical Site
RECRUITING

Manchester, M23 9QZ, United Kingdom
Sitryx Clinical Site
RECRUITING

Merthyr Tydfil, CF48 4DR, United Kingdom

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