Can a common antibiotic beat MRSA in kids? a trial puts TMP-SMX to the test
NCT ID NCT06982105
First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time
Summary
This trial compares two oral antibiotics—trimethoprim-sulfamethoxazole (TMP-SMX) and clindamycin—to see which works better for children with invasive MRSA infections, such as bone, joint, or deep tissue infections. About 100 children aged 60 days to 18 years will take one of the drugs and be monitored for treatment success and side effects over six months. The goal is to determine if TMP-SMX is a safe and effective alternative to clindamycin.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- trimethoprim-sulfamethoxazole (TMP-SMX) compared to clindamycin, both antibiotics
- What this could lead to
- If TMP-SMX proves as effective as clindamycin, it could offer a safe, alternative oral antibiotic for children with serious MRSA infections.
- What could go wrong
- This is a Phase 4 trial with 100 children, so results may not apply to all cases. TMP-SMX may cause side effects or be less effective than clindamycin.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for CERVICAL ADENITIS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Riley Hospital for Children
RECRUITINGIndianapolis, Indiana, 46202, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A quick test for septic arthritis in kids — could it save joints?
- Can a once-weekly antibiotic help people with opioid use disorder beat serious infections at home?
- Emergency room study aims to improve diagnosis of septic arthritis
- Scientists probe acid 'Pain Channels' in arthritic joints
- Mouth ultrasound could slash unnecessary throat punctures
- Researchers track Real-World treatment of serious ENT infections