Decubitus ulcer

This study tests whether adding special wound dressings (called CAMPs) to standard care helps heal pressure ulcers (bedsores) that won't close on their own. About 2,000 adults with stage 3 or 4 pressure sores will receive weekly applications of a CAMP product plus standard care, …

This study tests a special skin graft called NeoThelium FT to see if it can heal chronic pressure ulcers (bedsores) in 10 adults. The goal is complete wound closure within 16 weeks. Participants must have stage 2 or 3 ulcers on the pelvis or leg, without infection, and meet other…

This Phase II trial tests whether placing antibiotic-releasing beads (STIMULAN VG) into the wound during surgery, plus standard antibiotics, works better than standard care alone for bone infections linked to stage IV pressure ulcers. About 60 adults will be randomly assigned to …

This study tests a new way to create living skin during surgery for wounds that won't heal easily. Doctors take a small piece of the patient's own skin, separate out stem cells, and spray them onto a scaffold that is placed on the wound. The goal is to see if this helps wounds cl…

This study tests a community-based care bundle for treating and preventing pressure injuries (bedsores) in older adults at home. 216 participants discharged from Singapore General Hospital will either receive the bundle (including special cushions, skin barriers, and caregiver tr…

This phase 2 trial tests whether injecting antibiotics directly into the tissue around chronic wounds helps them heal better than standard care alone. About 60 adults with non-healing wounds on their legs, arms, or trunk will either receive the antibiotic injections plus usual wo…

This study tests a new hydrogel made with plasma-activated water on chronic wounds like diabetic foot ulcers and pressure sores. Fifty adults will either get the gel or standard wound care for 12 weeks. Researchers will check if the gel helps wounds close faster and lowers bacter…

This study tests whether a special vacuum-assisted wound system (NPWTi) helps heal chronic pressure sores better than standard wet-to-dry dressings. About 62 adults with stage 3 or 4 pressure sores on the tailbone or sitting bones will be randomly assigned to one of the two treat…

This study tests a program called PICU Up! that helps critically ill children start moving earlier while in the pediatric intensive care unit. The program includes daily activity plans, better sedation management, and family involvement. Researchers want to see if this approach r…

This study tests a gel called ZKARE® for treating chronic ulcers that won't heal on their own. About 134 people with pressure sores, diabetic foot ulcers, or leg ulcers will either get the gel plus standard care, or standard care alone. The goal is to see if the gel helps wounds …

This study tests whether a single-layer amniotic membrane (a thin tissue from donated placenta) plus standard wound care helps close nonhealing pressure ulcers better than standard care alone. About 100 adults with stage 3 or 4 pressure sores on the trunk will be followed for 20 …

This study tests whether adding a collagen scaffold called Miro3D to standard wound care helps acute and chronic wounds heal better than standard care alone. About 70 adults with soft tissue wounds or pressure ulcers will be randomly assigned to one of two groups. The main goal i…

This study tests a wound dressing called Miro3D, made from pig liver tissue, to see if it helps heal hard-to-treat wounds like diabetic foot ulcers and pressure ulcers. Up to 20 adults will receive the dressing along with standard care for up to 12 weeks. Researchers will measure…

This study tests a special wound covering made from donated placental tissue, called DermaBind TL, in 150 adults with diabetic foot or venous leg ulcers that won't heal. The goal is to see if the graft safely helps shrink or close the wound over 13 weeks. Participants must be 18-…

This study tests a new antibacterial absorbable dressing on 30 adults with chronic non-healing wounds. The dressing is designed to break down in the body and help wounds heal faster. Researchers will measure how much the wound shrinks after 3 weeks and how many wounds fully close…

This study tests a special powder dressing called Altrazeal for treating bedsores (pressure ulcers) in stages 2, 3, and 4. About 300 adults will either get this new dressing or standard care. The main goal is to see if the new dressing needs fewer changes and helps wounds heal be…

This study is testing a software tool called Belle.ai that uses artificial intelligence to help doctors diagnose common skin diseases. About 400 patients at dermatology clinics will have three photos taken of their skin condition. The AI will analyze the photos and suggest possib…

This study tests whether applying paraffin oil to the skin before using a tourniquet (a tight band that stops blood flow) during arm surgery can prevent skin injuries like redness, blisters, or burns. About 90 adults having elective upper arm surgery will be randomly assigned to …

This study compares two methods to prevent pressure ulcers (bedsores) in critically ill patients who must lie face-down (prone) for breathing support. About 262 ICU patients will receive either hyperoxygenated fatty acids or hydrocolloid dressings on at-risk areas. The goal is to…

This study works to prevent pressure injuries (bedsores) in hospitalized children and young people up to age 19. Researchers will improve a risk assessment tool to work better for those with dark skin tones. About 542 participants across 10 UK hospitals will help test the updated…

This study tests a decision support tool called CAPP-FIT to help prevent pressure injuries in people with spinal cord injury. About 808 veterans from 7 VA clinics will use a survey to identify risks, and providers get a report with recommended actions. The goal is to see if the t…

This early study is testing a mineral-based spray called THERAVEX on 26 people with various wounds, including burns, pressure sores, and diabetic ulcers. The spray is used alongside standard wound care to see if it helps the skin heal better and faster. So far, it appears safe an…

This study tests whether a cold helium plasma device is safe and tolerable for people with chronic wounds, such as leg ulcers or pressure sores. About 40 adults with wounds that have not healed for over 4 weeks will receive the treatment. The goal is to see if cold plasma can red…

This study looks at whether two physical therapy techniques—pulsed wound irrigation and electrical stimulation—can help heal pressure injuries (bedsores) in people with spinal cord injuries. Forty adults in rehab will receive one of three treatments: both techniques, irrigation a…

This study looks at whether continuously checking and adjusting the pressure of a breathing tube (laryngeal mask airway) can lower the chance of sore throat, hoarseness, and other throat problems in elderly patients after surgery. About 146 people aged 60 and older having non-eme…

This study tests whether using a virtual reality headset showing calming scenes (like puppies in a meadow) can reduce pain and discomfort for older adults in long-term care during wound dressing changes. Up to 20 residents will use VR for two weeks, with pain and mood measured be…

This study is checking how safe and effective a special dressing (3M V.A.C. Peel and Place) is when used with a standard wound vacuum therapy. About 90 adults with open wounds or surgical incisions will be treated and monitored. The goal is to see if the dressing helps wounds clo…

This study tests a group counseling program called Healing HEARTS to help people with conditions like obesity, skin disease, cancer, HIV, diabetes, or chronic pain deal with internalized stigma. Participants will either join the counseling program or a peer support group. The goa…

This study tests a new two-sided pad (Debrisoft Duo) for cleaning wounds by removing dead tissue. About 104 adults with various wound types (like diabetic ulcers or burns) will be randomly assigned to the new pad or the current one-sided pad. The main goal is to see if the new pa…

This study tests whether adhesive or elastic band devices are better at securing urinary catheters in critically ill patients. The goal is to prevent skin injuries, reduce discomfort, and lower the risk of catheter-related infections. About 188 adults in intensive care will be ra…

This study tests whether using a virtual reality headset showing nature scenes with relaxing music can reduce pain and anxiety during dressing changes for pressure sores. Sixty-two adults with pressure sores will be randomly assigned to either receive VR during dressing or standa…

This study is testing a pad used to clean wounds, such as diabetic ulcers, leg ulcers, pressure sores, surgical wounds, and burns. The goal is to see if the pad safely removes debris and improves the wound bed right after use. About 184 adults with these types of wounds will take…

This study tests whether zinc oxide or moist exposed wound ointment (MEBO) works better for healing stage 2 pressure ulcers (bedsores). About 76 adults in hospital wards will receive daily treatment, and nurses will track wound healing using a standard scoring tool. The goal is t…

This study looks at why wounds heal slowly or not at all in people with diabetes. Researchers will collect blood and wound fluid from 250 adults with chronic wounds to compare immune cells between diabetic and non-diabetic participants. The goal is to understand the biological re…

This study collects biological samples—like blood, skin biopsies, and swabs—from people with or at risk for skin diseases, as well as healthy volunteers. Researchers will use these samples to study the causes of skin conditions and explore potential treatments. Up to 700 particip…

This study tests whether a gamified metaverse-based training program helps nursing students learn more effectively about preventing and managing pressure ulcers (bedsores). Sixty second-year nursing students will be randomly assigned to either standard classroom teaching or stand…

This study looks at genetic and epigenetic changes in chronic wounds that don't heal normally. Researchers will compare tissue from the wound with blood samples from 256 adults to find genetic signatures linked to healing. The goal is to understand why some wounds heal and others…

This study tests whether an interactive e-book can improve home care nurses' knowledge and confidence in treating pressure injuries compared to standard PDF materials. About 132 nurses will use either the e-book or PDFs for one month and complete surveys before, right after, and …

This observational study follows 800 adults who receive Myriad™ during soft tissue reconstruction for wounds like abdominal dehiscence, pressure injuries, or anal fistulas. Researchers track healing time, complications, and side effects to understand how well the material works i…

This study tests whether an AI-powered mobile app can help ICU nurses more accurately identify and stage pressure injuries (bedsores) compared to standard visual checks. About 90 nurses will be split into two groups: one using the AI tool, the other doing manual assessments. Thei…

This study looks at how skin conditions related to cancer or cancer treatments affect the well-being of cancer patients and survivors. About 1,025 participants will fill out questionnaires about their skin condition. The goal is to better understand these effects and improve trea…

This early study tests a new sensor called E-SWEAT that fits inside a prosthetic leg socket. It measures sweat, pressure, and temperature to see how these factors affect skin health. Sixteen adults with below-knee amputations will wear the sensor while walking and doing a yoga po…