Can getting kids moving sooner in the ICU shorten their time on a ventilator?

NCT ID NCT04989790

Recruiting now Disease control Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a program called PICU Up! that helps critically ill children start moving earlier while in the pediatric intensive care unit. The program includes daily activity plans, better sedation management, and family involvement. Researchers want to see if this approach reduces how long children need a breathing machine and improves their overall recovery. The trial will involve 1,440 children across 10 U.S. hospitals.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PICU Up! early mobility program
What this could lead to: If effective, this program could become a new standard of care to help critically ill children recover faster and with fewer complications.
What could go wrong: This is a pragmatic trial testing a complex intervention across many hospitals, so results may vary. The study is not designed to prove a cure, only to improve recovery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Critical Illness critical illness polyneuropathy decubitus ulcer delirium postintensive care syndrome primary interstitial lung disease specific to childhood

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHILD CRITICAL ILLNESS HOSPITAL ACQUIRED PRESSURE ULCER INTENSIVE CARE UNIT ACQUIRED WEAKNESS

Contacts and locations

Locations

Children's Hospital at Dartmouth: Geisel School of Medicine
RECRUITING

Lebanon, New Hampshire, 03756, United States
Children's Hospital of Wisconsin: Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Hennepin Healthcare: University of Minnesota
RECRUITING

Minneapolis, Minnesota, 55415, United States
Janet Weis Children's Hospital: Geisinger Commonwealth School of Medicine
RECRUITING

Danville, Pennsylvania, 17822, United States
Johns Hopkins Hospital
ACTIVE_NOT_RECRUITING

Baltimore, Maryland, 21287, United States
Nemours Children's Hospital of the Nemours Foundation
RECRUITING

Orlando, Florida, 32827, United States
Norton Children's Hospital: University of Louisville
RECRUITING

Louisville, Kentucky, 40202, United States
Texas Children's Hospital: Baylor College of Medicine
RECRUITING

Houston, Texas, 77030, United States
UNC Children's: University of North Carolina
RECRUITING

Chapel Hill, North Carolina, 27514, United States
Valley Children's Hospital
RECRUITING

Madera, California, 93636, United States
West Virginia University Medicine Children's: West Virginia University
RECRUITING

Morgantown, West Virginia, 26506, United States

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