Critical illness polyneuropathy

This study tests whether a device called MyokinE100, which sends electrical signals to the thigh muscles, is safe and practical for use in the ICU. It includes 50 critically ill patients with sepsis who are at risk of muscle weakness. Half will receive standard care plus daily 60…

This study tests whether a 4-month structured telerehabilitation program, delivered via video calls and an app, can reduce deaths and hospital readmissions in heart patients who have Post-Intensive Care Syndrome (PICS). About 326 adults aged 30-75 who were in the ICU for at least…

This study tests a program called PICU Up! that helps critically ill children start moving earlier while in the pediatric intensive care unit. The program includes daily activity plans, better sedation management, and family involvement. Researchers want to see if this approach r…

This study tests whether using technology like handgrip games, virtual reality, and in-bed cycling, along with family help, can prevent muscle weakness in ICU patients on breathing machines. 138 critically ill adults will be split into three groups: one gets the tech-assisted pro…

This study tests whether giving ICU patients extra protein and activating their muscles early (using electrical stimulation and movement) can prevent severe muscle loss. About 40 critically ill adults on ventilators will take part. The goal is to see if this approach helps patien…

This study tests a device called Walkasins, worn on the lower legs, that vibrates to give sensory feedback about foot pressure. The goal is to see if using it daily for six months improves balance and walking in 200 adults aged 55+ with peripheral neuropathy. Participants will do…

This study tests a home-based exercise program for people who were hospitalized with severe COVID-19. Participants use a smartphone app to guide them through high-intensity interval training and other exercises. The goal is to see if this approach improves walking ability, fitnes…

This study tests a smartphone app called Tuntun Rehabilitation Assistant to help people who have been in the intensive care unit (ICU) regain strength and mobility. About 70 adults from two hospitals in South Korea will use the app for daily 30-minute rehab sessions. Researchers …

This study compares a high-tech rehabilitation program—using robotic systems, virtual reality, and balance platforms—to standard physical therapy for people with acute neuromuscular diseases like Guillain-Barré syndrome. About 124 adults aged 18 to 80 will participate. The goal i…

This study tests whether early, intensive respiratory physiotherapy can improve cough strength in ICU patients with muscle weakness who are struggling to come off a ventilator. Fifty adults on breathing machines will receive either three daily sessions of specialized breathing ex…

This study looks at whether moving patients on breathing machines out of bed and into a chair helps them regain strength and function better than staying in bed. About 150 adults in the ICU will be randomly assigned to either chair sitting or bed rest. The goal is to see if chair…

This study tests whether adding gentle electrical stimulation to physical therapy can help people who have had a severe stroke and developed muscle weakness in the ICU. About 24 participants will receive either standard therapy or therapy combined with functional electrical stimu…

This study follows 209 adults who survived a stay in the intensive care unit (ICU) for sepsis or respiratory failure. Researchers will track their muscle strength, physical function, and cellular markers over a year to understand why some patients recover while others do not. The…

This study looks at why some people who survive a serious illness in the ICU develop long-lasting muscle weakness. Researchers will test 50 former ICU patients with exercise on a bike to measure heart and muscle function. The goal is to better understand this condition, not to te…

This study aims to see if a quick bedside sensory test can predict which painkiller—pregabalin, duloxetine, or a placebo—works best for people with nerve pain in their feet. About 190 adults with diabetic, chemotherapy-related, or idiopathic nerve pain will try each treatment for…

This study tests two ways of cycling while lying in a hospital bed for patients in the intensive care unit (ICU). One method is steady cycling for 10-20 minutes, and the other is short bursts of harder cycling mixed with easier pedaling. The goal is to see which approach better a…

This study investigates whether serious muscle weakness, known to affect ICU patients, also occurs in people hospitalized outside the ICU. Researchers will follow about 600 adults in Italian hospitals, half with organ failure and half without, to see how often weakness develops a…

This pilot study is looking at why some patients in the intensive care unit (ICU) develop severe muscle weakness after surgery. Researchers will take blood and small muscle samples from 20 high-risk patients to look for chemical changes that might cause or signal this weakness. T…

This study is collecting information from 4,000 adults with peripheral neuropathy (nerve damage) to better understand the condition. Researchers will combine standard tests with nerve ultrasound to see if it helps diagnose and track the disease. No new treatments are being tested…

This study looks at whether giving ICU teams real-time feedback and extra nurse support helps them consistently use a set of proven care steps for patients on breathing machines. About 8,100 critically ill adults will take part across multiple ICUs. The goal is to find practical …

This study follows 100 adults who needed ECMO support for severe heart or lung failure. Researchers will track muscle size, strength, and quality of life over time to understand why some patients develop lasting weakness. No new treatments are being tested; the goal is to gather …

This study is collecting nerve samples and biofluids from 400 people with ALS or peripheral neuropathies to find biological markers for early diagnosis and disease tracking. By analyzing individual cells, researchers hope to identify molecular changes that happen before symptoms …

This study looks at 25 ICU patients who were on breathing machines for at least 2 days. Researchers want to see if a physical test called CPAx, done when leaving the ICU, can predict how well they walk 3 months later. The goal is to help doctors plan better rehab for patients aft…

This study tests a smart technology box for people who have been in the ICU. The goal is to see if it's possible for 50 patients to use the box at home for 12 months to monitor their health and catch problems early. The box is not a treatment, but a way to gather information to i…

This study follows 186 adults in the ICU to see if a physical function test called CPAx can predict serious outcomes like death or how long a patient needs a breathing machine. Researchers will measure function at ICU admission and discharge. The goal is to find a simple way to i…